{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:13:02Z","timestamp":1777486382141,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":330,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["IP 2011053771"],"award-info":[{"award-number":["IP 2011053771"]}]},{"name":"Ministry of Science and Higher Education","award":["2011\/01\/B\/NZ5\/02795"],"award-info":[{"award-number":["2011\/01\/B\/NZ5\/02795"]}]},{"name":"Ministry of Science and Higher Education","award":["IP 2011053771"],"award-info":[{"award-number":["IP 2011053771"]}]},{"name":"Ministry of Science and Higher Education","award":["2011\/01\/B\/NZ5\/02795"],"award-info":[{"award-number":["2011\/01\/B\/NZ5\/02795"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Family twin and adoption studies have noted the heritability of specific biological factors that influence suicidal behaviour. \n\t\t\t\t Exposure to stress is one of the factors that strongly contribute to suicide attempts. The biological response\n\t\t\t\t  to stress involves the hypothalamic\u2010pituitary\u2010adrenal axis (HPA). Therefore, we found it interesting to study polymorphisms of\n\t\t\t\t   genes involved in the HPA axis (<jats:italic>CRHR1, NR3C1,<\/jats:italic> and <jats:italic>AVPBR1<\/jats:italic>). The study was performed on\n\t\t\t\t    597 patients, 225 of whom had a history of suicide attempts. We did not observe any significant differences in the studied\n\t\t\t\t     polymorphisms between the group of patients with a history of suicide attempts and the control subjects. Our haplotype analysis\n\t\t\t\t      of the <jats:italic>AVPR1b<\/jats:italic> gene revealed an association between the GCA haplotype and suicide attempts; however,\n\t\t\t\t       this association was not significant after correcting for multiple testing. We did not observe any other association in haplotype\n\t\t\t\t        and MDR analysis. We report here a comprehensive analysis of the HPA axis genes and a lack of association for genetic\n\t\t\t\t         variations regarding the risk of suicide attempts in affective disorder patients. Nonetheless, the inconsistencies with the previously\n\t\t\t\t          published results indicate the importance of the further investigation of these polymorphisms with respect to the risk of suicide attempts.<\/jats:p>","DOI":"10.1155\/2013\/207361","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T22:57:54Z","timestamp":1385593074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association, Haplotype, and Gene\u2010Gene Interactions of the HPA Axis Genes with Suicidal Behaviour in Affective Disorders"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-9190","authenticated-orcid":false,"given":"Anna","family":"Leszczy\u0144ska-Rodziewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Szczepankiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Dmitrzak-Weglarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.12.016"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.12.012"},{"key":"e_1_2_8_3_2","unstructured":"PawlakJ. Dmitrzak-W\u0119glarzM. SkibinskaM. SzczepankiewiczA. Leszczynska-RodziewiczA. CzerskiP. ZarembaD. HauserJ. andMaciukiewiczM. Association between suicidal behavior and genes of serotonergic system in affective disorders in press Nowiny Lekarskie 2013."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.08.009"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/13811110600993124"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.11.017"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0108-z"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.04.008"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.10.015"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.10.007"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.07.012"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4734-03.2004"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.08.001"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.08.018"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.07.007"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2270"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.10.050"},{"key":"e_1_2_8_18_2","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV)","author":"First M. B.","year":"1996"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.01.025"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.10.1189"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.49"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00310.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00446.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.26"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001587"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.12.013"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.02.017"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2006.12.001"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108097817"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.06.020"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/207361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/207361.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2013\/207361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T14:46:51Z","timestamp":1720277211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2013\/207361"}},"subtitle":[],"editor":[{"given":"D.","family":"Ndetei","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"M.","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1155\/2013\/207361"],"URL":"https:\/\/doi.org\/10.1155\/2013\/207361","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2013-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"207361"}}