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In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup>exchangers (NHEs) are electroneutral Na<jats:sup>+<\/jats:sup>-dependent proteins that exchange extracellular Na<jats:sup>+<\/jats:sup>for intracellular H<jats:sup>+<\/jats:sup>. To date, there are 9 identified NHE isoforms where NHE1 is the most ubiquitous member, known as the housekeeping exchanger. NHE1 seems to have a protective role in the ischemia-reperfusion injury and other inflammatory diseases. In nociception, NHE1 is found in neurons along nociceptive pathways, and its pharmacological inhibition increases nociceptive behavior in acute pain models at peripheral and central levels. Electrophysiological studies also show that NHE modulates electrical activity of primary nociceptive terminals. However, its role in neuropathic pain still remains controversial. In humans, NHE1 may be responsible for inflammatory bowel diseases since its expression is reduced in Crohn\u2019s disease and ulcerative colitis. The purpose of this work is to provide a review of the evidence about participation of NHE1 in the nociceptive processing.<\/jats:p>","DOI":"10.1155\/2013\/217864","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T21:02:11Z","timestamp":1359579731000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Role of NHE1 in Nociception"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jorge El\u00edas","family":"Torres-L\u00f3pez","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Posgrado y Divisi\u00f3n Acad\u00e9mica de Ciencias de la Salud, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, 86040 Villahermosa, TAB, Mexico"},{"name":"Hospital Regional de Alta Especialidad \u201cDr. Juan Graham Casas\u00fas\u201d, 86126 Villahermosa, TAB, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystell 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