{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:13:00Z","timestamp":1791389580269,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100008836","name":"Gaziantep University","doi-asserted-by":"crossref","award":["TF.08.08"],"award-info":[{"award-number":["TF.08.08"]}],"id":[{"id":"10.13039\/501100008836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    This study was performed to determine the distribution of\n                    <jats:italic>Candida<\/jats:italic>\n                    species isolated from the blood cultures of the patients hospitalized in our hospital and to investigate their antifungal susceptibility.\n                    <jats:italic>Candida<\/jats:italic>\n                    strains were identified at species level by using classical methods and API ID 32C (bioMerieux, France) identification kits. The susceptibility of the strains to amphotericin B, fluconazole, voriconazole, and caspofungin was evaluated by using the reference broth microdilution method in document M27\u2010A3 of the Clinical and Laboratory Standards Institute. Of the 111\n                    <jats:italic>Candida<\/jats:italic>\n                    strains isolated, 47.7% were identified as\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and 52.3% as non\u2010albicans\n                    <jats:italic>Candida<\/jats:italic>\n                    strains. The MIC ranges were 0.03\u20131\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL for amphotericin B, 0.125\u2013\u226564\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL for fluconazole, 0.03\u201316\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL for voriconazole, and 0.015\u20130.25\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL for caspofungin. All\n                    <jats:italic>Candida<\/jats:italic>\n                    strains were susceptible to amphotericin B and caspofungin. 10.8% isolates were resistant to fluconazole and 8.1% isolates were dose\u2010dependent susceptible. While 0.9% isolate was resistant to voriconazole, 0.9% isolate was dose\u2010dependent susceptible. In our study,\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    were the most frequently encountered agents of candidemia and it was detected that voriconazole with a low resistance rate might also be used with confidence in the treatment of infections occurring with these agents, primarily besides amphotericin B and caspofungin.\n                  <\/jats:p>","DOI":"10.1155\/2013\/236903","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T17:38:43Z","timestamp":1382463523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["In Vitro Susceptibility of\n                    <i>Candida<\/i>\n                    Species to Four Antifungal Agents Assessed by the Reference Broth Microdilution Method"],"prefix":"10.1155","volume":"2013","author":[{"given":"Fahriye","family":"Eksi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efgan Dogan","family":"Gayyurhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iclal","family":"Balci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.2.281-310.2004"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0822-1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_2_8_5_2","first-page":"73","article-title":"Epidemiology of candidemia","volume":"17","author":"Sandven P.","year":"2000","journal-title":"Revista Iberoamericana de Micologia"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.01003.x"},{"key":"e_1_2_8_7_2","first-page":"15","article-title":"Antifungal resistance: the clinical front","volume":"18","author":"Perfect J. R.","year":"2004","journal-title":"Oncology"},{"key":"e_1_2_8_8_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Third Edition. CLSI Document M27-A3","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2008"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3475-3482.2004"},{"key":"e_1_2_8_10_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Third Informational Supplement. CLSI Document M27-S3","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2008"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4419-4431.2004"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00662.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh548"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2002.00446.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1782-1787.2006"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.00971.x"},{"key":"e_1_2_8_17_2","first-page":"1949","volume-title":"Manual of Clinical Microbiology","author":"Arikan S.","year":"2007"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg073"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762003000300020"},{"key":"e_1_2_8_20_2","first-page":"252","article-title":"In vitro susceptibility to Amphotericin B and Fluconazole of Candida strains isolated froom blood cultures","volume":"33","author":"Toprak N. \u00dc.","year":"2003","journal-title":"T\u00fcrk Mikrobiyoloji Cemiyeti Dergisi"},{"key":"e_1_2_8_21_2","first-page":"146","article-title":"Antifungal susceptibility of Candida albicans isolates recovered from blood cultures of intensive care unit patients","volume":"21","author":"Yenisehirli G.","year":"2007","journal-title":"Ankem Dergisi"},{"key":"e_1_2_8_22_2","first-page":"116","article-title":"Susceptibility of 300 Candida albicans strains to amphotericin B, flucytosine, flukonazole ve mikonazole","volume":"11","author":"Kiraz N.","year":"1998","journal-title":"Klimik Dergisi"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1298-1302.2002"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf060"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00163-06"},{"key":"e_1_2_8_26_2","first-page":"294","article-title":"Susceptibility of yeasts to antifungal agents in Kaunas University of Medicine Hospital","volume":"42","author":"Skrodeniene E.","year":"2006","journal-title":"Medicina"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MYCO.0000020594.35357.b0"},{"key":"e_1_2_8_28_2","first-page":"7","article-title":"The species distrubition and antifungal susceptibility pattern of yeasts and molds isolated in the Department of Microbiology and Clinical Microbiology Deep Mycoses Laboratory between 01 April 1999-27 March 2001","volume":"33","author":"Kantarcioglu A. S.","year":"2002","journal-title":"Cerrahpasa Journal of Medicine"},{"key":"e_1_2_8_29_2","first-page":"14","article-title":"Typing of yeasts isolated from the specimens of neutropenic patients and investigation of fluconazole resistance","volume":"14","author":"Kaya D.","year":"2001","journal-title":"Klimik Dergisi"},{"key":"e_1_2_8_30_2","first-page":"210","article-title":"New antifungal agents","volume":"21","author":"Kebudi R.","year":"2007","journal-title":"Ankem Dergisi"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01900-06"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01840-06"},{"key":"e_1_2_8_33_2","first-page":"223","article-title":"In-vitro susceptibilities of nonalbicans Candida and Yeasts other tan Candida Species isolated from patients with hematologic malignancies to fluconazole and voriconazole","volume":"21","author":"Ke\u00e7eli \u00d6zcan S.","year":"2007","journal-title":"Ankem Dergisi"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.512023"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.760-763.2006"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/236903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2013\/236903.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2013\/236903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T11:00:50Z","timestamp":1720263650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2013\/236903"}},"subtitle":[],"editor":[{"given":"A.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"A.","family":"Ouwehand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1155\/2013\/236903"],"URL":"https:\/\/doi.org\/10.1155\/2013\/236903","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2013-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"236903"}}