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In addition, the runners of this substrain cover a significantly smaller distance than the average runners of two other substrains, namely, the BALB\/c ByJ and the BALB\/c AnNCrl. The latter shows a striking level of voluntary activity, with the average distance run\/day reaching up to about 12 kilometers. These runners are not outstanders, but they represent the majority of the population, with important scientific and economic fallouts to be taken into account during experimental planning. Spontaneous activity persists in pathological conditions, such as cancer\u2010associated cachexia. 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