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Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>sac<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>sac<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>) on cardiac electrical excitation conduction and mechanical contraction. At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>sac<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>) and a mechanical model. At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations. The simulation results showed that Fbs and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>sac<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue. This preliminary simulation study indicates that Fbs and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>sac<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.<\/jats:p>","DOI":"10.1155\/2013\/238676","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T17:01:04Z","timestamp":1376413264000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current: A Simulation Study"],"prefix":"10.1155","volume":"2013","author":[{"given":"Heqing","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.101410"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9667-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(03)00022-1"},{"key":"4","first-page":"43","volume":"2","year":"2011","journal-title":"Frontiers in Physiology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223610"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00324.2011"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2010.05.008"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"H144","DOI":"10.1152\/ajpheart.01151.2011","volume":"303","year":"2012","journal-title":"American Journal of Physiology. 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