{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:57:12Z","timestamp":1793235432225,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The aim of this study was to evaluate if patients with Behcet\u2019s disease who have ocular involvement have a more severe form of this disease as compared to patients with Behcet\u2019s disease alone.<jats:italic>Methods<\/jats:italic>. A total of 99 patients were included in the study. 76 patients were used as part of the examined group, and 23 patients formed a control group.<jats:italic>Results<\/jats:italic>. The following are the results of examined and control groups, respectively: recurrent oral aphthous ulcers 89.5%, 95.7%; genital ulcers 61.8%, 97.0%; articular involvement 72.4%, 65.2%; vasculitis 81.6%, 60.9%; positive pathergy test 25.0%, 47.8%. Higher frequency of genital ulcerations was noted in control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). More than two major criteria were met in 100% of the cases. HLA B51 was present in 78.9% of the cases in the examined group and 43.5% of the cases in control group; thus there is significant difference between them (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Visual acuity &gt;0.5 occurred in 76% (examined group). Most frequent ocular manifestations in the examined group were retinal periphlebitis 81.6%, periphlebitis and periarteritis 65%, and serofibrinous uveitis 63.2%. Macular edema as a complication was present in 63.2%. The majority of patients (55.3%) were treated with combined therapy consisting of cyclosporine A and systemic corticosteroids. In 38.2% of patients, laser photocoagulation was used on retinal periphery.<\/jats:p>","DOI":"10.1155\/2013\/247345","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T17:02:21Z","timestamp":1380819741000},"page":"1-7","source":"Crossref","is-referenced-by-count":41,"title":["Behcet\u2019s Disease: Systemic and Ocular Manifestations"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jelena","family":"Paovic","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Clinical Centre of Belgrade, Pasterova 2, Belgrade 11000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-9337","authenticated-orcid":true,"given":"Predrag","family":"Paovic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Centre of Belgrade, Pasterova 2, Belgrade 11000, 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