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Iron may promote the stress by the Fenton reaction, so its homeostasis should be strictly controlled. Transferrin is essential for iron homeostasis because it transports iron from plasma into cells. The malfunction of transferrin, which may be caused by variation in its gene (<jats:italic>TF<\/jats:italic>) variation, may contribute to oxidative stress and change KC and FECD risk. To verify this hypothesis we investigated the association between three polymorphisms of the<jats:italic>TF<\/jats:italic>gene, g.3296G&gt;A (rs8177178), g.3481A&gt;G (rs8177179), and c.\u20132G&gt;A (rs1130459), and KC and FECD occurrence. Genotyping was performed in blood lymphocytes in 216 patients with KC, 130 patients with FECD and 228 controls by PCR-RFLP. We studied also the influence of other risk factors. The A\/A genotype and the A allele of the g.3296G&gt;A polymorphism were associated with KC occurrence, while the G allele was negatively correlated with it. We observed a decrease in KC occurrence associated with the A\/G genotype of the g.3481A&gt;G polymorphism. We did not find any association between the c.\u20132G&gt;A polymorphism and KC. No association was found between all three polymorphisms and FECD occurrence.<\/jats:p>","DOI":"10.1155\/2013\/247438","type":"journal-article","created":{"date-parts":[[2013,11,24]],"date-time":"2013-11-24T16:01:02Z","timestamp":1385308862000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Polymorphism of the Transferrin Gene in Eye Diseases: Keratoconus and Fuchs Endothelial Corneal Dystrophy"],"prefix":"10.1155","volume":"2013","author":[{"given":"Katarzyna A.","family":"W\u00f3jcik","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Synowiec","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, University of Lodz, Pomorska 141\/143, 90-236 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel 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