{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:53:46Z","timestamp":1770677626918,"version":"3.49.0"},"reference-count":74,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetics Research International"],"published-print":{"date-parts":[[2013,12,31]]},"abstract":"<jats:p>Behcet\u2019s disease (BD) is a systemic, chronic inflammatory disorder with both innate and adaptive immune responses. Heat shock proteins (HSP) are highly conserved molecules in different species with scavenger activity and involved in correct folding of newly synthesized proteins. T and B cell responses against HSPs are observed in BD patients in both<jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>\u03b1<\/mml:mi><mml:mi>\u03b2<\/mml:mi><\/mml:math><\/jats:inline-formula>and<jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>\u03b3<\/mml:mi><mml:mi>\u03b4<\/mml:mi><\/mml:math><\/jats:inline-formula>T-cell populations. 60-kD HSP (HSP60) is also shown to be recognized by pattern recognition receptors such as toll-like receptors (TLR) and is suggested to be an endogenous \u201cdanger\u201d signal to the immune system with rapid inflammatory cytokine releases and enhancement of adaptive Th1-type responses. Elucidating the exact role of HSPs in BD pathogenesis might pave the way to less toxic therapeutic approaches to BD, such as antibacterial therapies and immunomodulation.<\/jats:p>","DOI":"10.1155\/2013\/249157","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T21:01:08Z","timestamp":1388523668000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Innate and Adaptive Responses to Heat Shock Proteins in Behcet\u2019s Disease"],"prefix":"10.1155","volume":"2013","author":[{"given":"H.","family":"Direskeneli","sequence":"first","affiliation":[{"name":"Division of Rheumatology, School of Medicine, Marmara University Hospital, Marmara University, Fevzi \u00c7akmak Mah, Mimar Sinan Cadde No. 41, Pendik, 34890 Istanbul, 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