{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:07:51Z","timestamp":1787731671843,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the ESUR scoring system (PI-RADS) for multiparametric MRI of the prostate in clinical routine and to define a reliable way to generate an overall PI-RADS score.<jats:italic>Methods<\/jats:italic>. Retrospective analysis of all patients with a history of negative prebiopsies, who underwent 3 Tesla multiparametric MRI from October 2011 to April 2013 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>143<\/mml:mn><\/mml:math>): PI-RADS scores for each single modality were defined. To generate the overall PI-RADS score, an algorithm based approach summing up each single-modality score to a sum-score was compared to a more subjective approach, weighting the single modalities dependent on the radiologist\u2019s impression. Because of ongoing cancer suspicion 73 patients underwent targeted mpMRI-ultrasound image fusion rebiopsy. For this group thresholds for tumor incidences and malignancy were calculated.<jats:italic>Results<\/jats:italic>. 39 (53%) out of 73 targeted rebiopsies were cancer positive. The PI-RADS score correlated well with tumor incidence (AUC of 0.86, 95% CI 0.78 to 0.94) and malignancy (AUC 0.84, 95% CI 0.68 to 0.99). Regarding the sum-score a threshold of \u226510 turned out to be reliable for cancer detection (sensitivity 90%, specificity 62%) and for \u226513 for indicating higher malignancy (Gleason<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo>\u2265<\/mml:mo><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:math>) (sensitivity 80%, specificity 86%). To generate the overall PI-RADS score, the use of an algorithm based approach was more reliable than that of the approach based on the radiologist\u2019s impression.<jats:italic>Conclusion<\/jats:italic>. The presented scoring system correlates well with tumor incidence and malignancy. To generate the overall PI-RADS score, it seems to be advisable to use an algorithm based instead of a subjective approach.<\/jats:p>","DOI":"10.1155\/2013\/252939","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T16:02:05Z","timestamp":1387209725000},"page":"1-9","source":"Crossref","is-referenced-by-count":48,"title":["Evaluation of the PI-RADS Scoring System for Classifying mpMRI Findings in Men with Suspicion of Prostate Cancer"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-1467","authenticated-orcid":true,"given":"Daniel","family":"Junker","sequence":"first","affiliation":[{"name":"Department of Radiology, Medical University of Innsbruck, Anichstra\u00dfe 35, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Innsbruck, Anichstra\u00dfe 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