{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:24:59Z","timestamp":1790202299120,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"BACKGROUND: Nocardia<\/jats:italic> species are rare, opportunistic organisms that cause disease in both immunocompetent and immunocompromised individuals.<\/jats:p>OBJECTIVE: To investigate the clinical presentations of various Nocardia<\/jats:italic> infections based on the 16S ribosomal RNA gene of the isolate, as well as related risk factors and susceptibility patterns to antimicrobial agents<\/jats:p>METHODS: Thirteen patients with a diagnosis of nocardiosis were included in the present study. Seven Nocardia<\/jats:italic> species were identified by 16S ribosomal RNA. Susceptibility testing was performed using six antimicrobial agents.<\/jats:p>RESULTS: Five patients were immunocompromised, and eight were immunocompetent with predisposing factors including cystic fibrosis, tuberculosis and ophthalmic infections. Nocardia<\/jats:italic> caused pulmonary infections in eight patients (61.5%), invasive systemic infections in three patients (23%) and local (ophthalmic) infections in two patients (15.4%). In the patients with pulmonary disease, nocardiosis was caused by six species (Nocardia cyriacigeorgica<\/jats:italic>, Nocardia otitidiscaviarum<\/jats:italic>, Nocardia farcinica<\/jats:italic>, Nocardia carnea<\/jats:italic>, Nocardia testacea<\/jats:italic> and Nocardia asiatica)<\/jats:italic>. The seventh species identified in the present study was Nocardia crassostreae.<\/jats:italic><\/jats:p>DISCUSSION: N crassostreae<\/jats:italic> is a multidrug\u2010resistant organism that was reported to be an emerging human pathogen causing invasive nocardiosis in a patient with non\u2010Hodgkin\u2019s lymphoma. N farcinica<\/jats:italic> was isolated from blood in a patient with breast cancer. None of the Nocardia<\/jats:italic> isolates were resistant to linezolid. One N otitidiscaviarum<\/jats:italic> isolate was a multidrug\u2010resistant organism. All patients in the present study were treated with the appropriate antibiotics and their condition resolved without further sequelae.<\/jats:p>CONCLUSIONS: The present study is the first report on N crassostreae<\/jats:italic> as a human pathogen. The detection of multidrug\u2010resistant species necessitate molecular identification and susceptibility testing, and should be performed for all Nocardia<\/jats:italic> infections. Nocardiosis manifests various clinical features depending on the Nocardia<\/jats:italic> species and underlying conditions.<\/jats:p>","DOI":"10.1155\/2013\/256025","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:52:02Z","timestamp":1458028322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Identification and Susceptibility Pattern of Clinical Nocardia<\/i> Species: Emergence of Nocardia crassostreae<\/i> as an Agent of Invasive Nocardiosis"],"prefix":"10.1155","volume":"24","author":[{"given":"Saad J","family":"Taj-Aldeen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Doiphode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atqah","family":"Abdul Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Allangawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"AlMuzrkchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corn\u00e9 H","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2013\/256025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2013\/256025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:12:52Z","timestamp":1723075972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2013\/256025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1155\/2013\/256025"],"URL":"https:\/\/doi.org\/10.1155\/2013\/256025","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2013-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}