{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:46:52Z","timestamp":1758268012185,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["5U2RTW 006885"],"award-info":[{"award-number":["5U2RTW 006885"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["5U2RTW 006885"],"award-info":[{"award-number":["5U2RTW 006885"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pulmonology"],"published-print":{"date-parts":[[2013,1,21]]},"abstract":"<jats:p>The <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>M. tb<\/jats:italic>) infection is largely spread in world's population. Most infected individuals develop latent tuberculosis infection (LTBI). Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are the available tests to detect the infection. It has been reported that some individuals take a longer period of time to develop the infection than others with the same exposure level. It is suggested that the innate immunity, in which neutrophils have an important protective role, is responsible for this. Many hematologic abnormalities have been described as common findings during severe disease. To investigate if these changes are related to LTBI development and if they interfere in TST and IFN-<jats:italic>\u03b3<\/jats:italic> production, we recruited 88 household contacts of tuberculosis (TB) pulmonary patients and compared blood cell counts with these tests' results. There were no statistically significant changes in hemoglobin, hematocrit, platelets, global leukocyte, neutrophils, basophils, eosinophils, typical lymphocytes, atypical lymphocytes, and monocytes counts between infected and noninfected individuals. Also, there was no correlation between TST or IGRA and blood cell counts. These results suggest that blood cell counts are not LTBI markers and do not interfere in TST results or IFN-<jats:italic>\u03b3<\/jats:italic> levels obtained by IGRA.<\/jats:p>","DOI":"10.1155\/2013\/256148","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:01:31Z","timestamp":1358802091000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection"],"prefix":"10.1155","volume":"2013","author":[{"given":"Iukary","family":"Takenami","sequence":"first","affiliation":[{"name":"Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gon\u00e7alo Moniz Research Center, 40296 710 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Bahia School of Medicine and Public Health, 40290 000 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alm\u00e9rio","family":"Machado","sequence":"additional","affiliation":[{"name":"Bahia School of Medicine and Public Health, 40290 000 Salvador, BA, Brazil"},{"name":"Hospital Especializado Oct\u00e1vio Mangabeira, Secretariat of Health of Bahia State, 40320 350 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Emodi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee W.","family":"Riley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"Arruda","sequence":"additional","affiliation":[{"name":"Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gon\u00e7alo Moniz Research Center, 40296 710 Salvador, BA, Brazil"},{"name":"Bahia School of Medicine and Public Health, 40290 000 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2011","key":"1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.8.6.1089-1096.2001"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6707-6714.2002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.02.032"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00561.x"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1164\/rccm.200402-179OC","volume":"170","year":"2004","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa031667"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-56"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31097"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.125.4.691"},{"issue":"272","key":"13","first-page":"1151","volume":"73","year":"1989","journal-title":"Quarterly Journal of Medicine"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/1097-0142(197709)40:3<1276::AID-CNCR2820400342>3.0.CO;2-X","volume":"40","year":"1977","journal-title":"Cancer"},{"issue":"4, part 2","key":"15","first-page":"S221","volume":"161","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"15","key":"16","first-page":"49","volume":"54","year":"2005","journal-title":"MMWR. 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