{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:26:57Z","timestamp":1782170817411,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa Cient\u00edfica e Tecnol\u00f3gica do Estado de Santa Catarina"},{"name":"Programa Iberoamericano de Ci\u00eancia y Tecnologia para el Desarrollo"},{"name":"University of Vale do Itaja\u00ed"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>This study evaluated extracts, fractions, and isolated compounds from some selected Brazilian medicinal plants against strains of promastigotes of<jats:italic>Leishmania amazonensis<\/jats:italic>and<jats:italic>L. brasiliensis in vitro<\/jats:italic>. The cell viability was determined, comparing the results with reference standards. The dichloromethane fractions of the roots, stems, and leaves of<jats:italic>Allamanda schottii<\/jats:italic>showed IC<jats:sub>50<\/jats:sub>values between 14.0 and 2.0\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. Plumericin was the main active compound, with IC<jats:sub>50<\/jats:sub>of 0.3 and 0.04\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL against the two species of<jats:italic>Leishmania<\/jats:italic>analyzed. The hexane extract of<jats:italic>Eugenia umbelliflora<\/jats:italic>fruits showed IC<jats:sub>50<\/jats:sub>of 14.3 and 5.7\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL against<jats:italic>L. amazonensis<\/jats:italic>and<jats:italic>L. brasiliensis<\/jats:italic>, respectively. The methanolic extracts of the seeds of<jats:italic>Garcinia achachairu<\/jats:italic>and guttiferone A presented IC<jats:sub>50<\/jats:sub>values of 35.9 and 10.4\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, against<jats:italic>L. amazonensis<\/jats:italic>, respectively. The ethanolic extracts of the stem barks of<jats:italic>Rapanea ferruginea<\/jats:italic>and the isolated compound, myrsinoic acid B, presented activity against<jats:italic>L. brasiliensis<\/jats:italic>with IC<jats:sub>50<\/jats:sub>of 24.1 and 6.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. Chloroform fraction of<jats:italic>Solanum sisymbriifolium<\/jats:italic>exhibited IC<jats:sub>50<\/jats:sub>of 33.8 and 20.5\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, and cilistol A was the main active principle, with IC<jats:sub>50<\/jats:sub>of 6.6 and 3.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL against<jats:italic>L. amazonensis<\/jats:italic>and<jats:italic>L. brasiliensis<\/jats:italic>, respectively. It is concluded that the analyzed plants are promising as new and effective antiparasitic agents.<\/jats:p>","DOI":"10.1155\/2013\/265025","type":"journal-article","created":{"date-parts":[[2013,6,9]],"date-time":"2013-06-09T17:00:35Z","timestamp":1370797235000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles"],"prefix":"10.1155","volume":"2013","author":[{"given":"Valdir Cechinel","family":"Filho","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas (PPGCF), Universidade do Vale do Itaja\u00ed, Rua Uruguai, 458, Centro, 88302-202 Itaja\u00ed, SC, Brazil"},{"name":"N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed, Rua Uruguai, 458, Centro, 88302-202 Itaja\u00ed, SC, 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