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In the absence of familial history and other clinical findings, the proportion of thoracic and abdominal aortic aneurysms and dissections resulting from a genetic predisposition is still unknown. In this study, we propose the review of the current genetic knowledge in the aortic disease, observing, in the results that the causative genes and molecular pathways involved in the pathophysiology of aortic aneurysm disease remain undiscovered and continue to be an area of intensive research.<\/jats:p>","DOI":"10.1155\/2013\/267215","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T22:00:28Z","timestamp":1358200828000},"page":"1-7","source":"Crossref","is-referenced-by-count":35,"title":["Aortic Disease in the Young: Genetic Aneurysm Syndromes, Connective Tissue Disorders, and Familial Aortic Aneurysms and Dissections"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-2251","authenticated-orcid":true,"given":"Marcelo","family":"Cury","sequence":"first","affiliation":[{"name":"Instituto de Cirurgia Vascular e Endovascular (ICVE), S\u00e3o Paulo, SP, 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