{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:05Z","timestamp":1740164585709,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Minimal Change Disease (MCD) is the most common cause of nephrotic syndrome in children, while IgA nephropathy is the most common cause of glomerulonephritis worldwide. MCD is responsive to glucocorticoids, while the role of steroids in IgA nephropathy remains unclear. We describe a case of two distinct clinical and pathological findings, raising the question of whether MCD and IgA nephropathy are separate entities or if there is a common pathophysiology.<jats:italic>Case Report<\/jats:italic>. A 19-year old man with no medical history presented to the Emergency Department with a 20-day history of anasarca and frothy urine, BUN 68\u2009mg\/dL, Cr 2.3\u2009mg\/dL, urinalysis 3+ RBCs, 3+ protein, and urine protein\u2009:\u2009creatinine ratio 6.4. Renal biopsy revealed hypertrophic podocytes on light microscopy, podocyte foot process effacement on electron microscopy, and immunofluorescent mesangial staining for IgA. The patient was started on prednisone and exhibited dramatic improvement.<jats:italic>Discussion<\/jats:italic>. MCD typically has an overwhelming improvement with glucocorticoids, while the resolution of IgA nephropathy is rare. Our patient presented with MCD with the uncharacteristic finding of hematuria. Given the improvement with glucocorticoids, we raise the question of whether there is a shared pathophysiologic component of these two distinct clinical diseases that represents a clinical variant.<\/jats:p>","DOI":"10.1155\/2013\/268401","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T17:04:22Z","timestamp":1369155862000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Minimal Change Disease and IgA Deposition: Separate Entities or Common Pathophysiology?"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-3955","authenticated-orcid":true,"given":"Brandon S.","family":"Oberweis","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University, School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-8238","authenticated-orcid":true,"given":"Aditya","family":"Mattoo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, New York University, School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-1169","authenticated-orcid":true,"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University, School of Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Division of Nephrology, New York University, School of Medicine, New York, NY, USA"},{"name":"Nephrology Section, New York Harbor VA Medical Center, 111G New York DVAMC, 423 E. 23 Streat New York, NY 10010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ki.1981.209","volume":"20","year":"1981","journal-title":"Kidney International"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03531006"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ki.1995.50","volume":"47","year":"1995","journal-title":"Kidney International"},{"issue":"7","key":"4","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1681\/ASN.2005020134","volume":"16","year":"2005","journal-title":"Journal of the American Society of Nephrology"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3349\/ymj.1990.31.3.258","volume":"31","year":"1990","journal-title":"Yonsei Medical Journal"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/ajcp\/86.6.716","volume":"86","year":"1986","journal-title":"American Journal of Clinical Pathology"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0272-6386(89)80168-4","volume":"14","year":"1989","journal-title":"American Journal of Kidney Diseases"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.10.2279"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/BF01540430","volume":"33","year":"1988","journal-title":"Digestive Diseases and Sciences"},{"issue":"3","key":"10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0272-6386(87)80053-7","volume":"9","year":"1987","journal-title":"American Journal of Kidney Diseases"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/00313029500169053"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2013\/268401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2013\/268401.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2013\/268401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T09:27:47Z","timestamp":1498037267000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crin\/2013\/268401\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":11,"alternative-id":["268401","268401"],"URL":"https:\/\/doi.org\/10.1155\/2013\/268401","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"type":"print","value":"2090-6641"},{"type":"electronic","value":"2090-665X"}],"subject":[],"published":{"date-parts":[[2013]]}}}