{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:26:47Z","timestamp":1762252007669,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002994","name":"Korea Ministry of Knowledge and Economy","doi-asserted-by":"crossref","award":["10042208"],"award-info":[{"award-number":["10042208"]}],"id":[{"id":"10.13039\/501100002994","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>G-protein coupled receptor 119 (GPR119) has emerged as a promising new target for the treatment of type 2 diabetes mellitus. The expression of GPR119 on the pancreatic B cells and intestinal L cells provides a unique opportunity for a single drug to promote insulin and GLP-1 secretion. In this study, we identified a novel small molecule GPR119 agonist, HD0471953, from our large library of synthetic compounds based on its ability to anti-hyperglycemic effects on T2DM murine models. We have tested the acute efficacy of HD0471953 by the oral glucose tolerance test (OGTT) with normal C57BL\/6J mice. Then, chronic administrations of HD0471953 were performed to evaluate the efficacy on various diabetic rodent models. Single administration of HD0471953 showed improved glycemic control with a dose-dependent manner in OGTT with normal mice, and the insulin and GLP-1 were also increased. To identify chronic efficacy, we have observed a decline of blood glucose and fasting insulin in a dose-dependent manner of 10, 20, and 50\u2009mpk in<jats:italic>db\/db<\/jats:italic>mice. The results suggest that HD0471953 may be a potentially promising anti-hyperglycemic agent for the treatment of patients with type 2 diabetes mellitus.<\/jats:p>","DOI":"10.1155\/2013\/269569","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T16:01:29Z","timestamp":1386604889000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["In Vivo Efficacy of HD0471953: A Novel GPR119 Agonist for the Treatment of Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2013","author":[{"given":"So Ra","family":"Kim","sequence":"first","affiliation":[{"name":"Hyundai Pharmaceutical Co. Ltd., 204-4 Nonhyeon 1-dong, Gangnam-gu, Seoul 135-545, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Hyundai Pharmaceutical Co. Ltd., 204-4 Nonhyeon 1-dong, Gangnam-gu, Seoul 135-545, Republic of Korea"},{"name":"College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Seoul 135-545, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Seoul 135-545, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Hyundai Pharmaceutical Co. Ltd., 204-4 Nonhyeon 1-dong, Gangnam-gu, Seoul 135-545, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Hyundai Pharmaceutical Co. 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