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The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.<\/jats:p>","DOI":"10.1155\/2013\/270362","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T03:24:32Z","timestamp":1365045872000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases"],"prefix":"10.1155","volume":"2013","author":[{"given":"Anthony C.","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, Victoria Hospital, London Health Science Centre, Room B3-431A, 800 Commissioners Road East, London, ON, Canada N6A 5W9"},{"name":"London Regional Cancer Program, London, ON, Canada N6A 4L6"},{"name":"Lawson Health Research Institute, London, ON, Canada N6C 2R5"},{"name":"Department of Oncology, The University of Western Ontario, London, ON, N6A 4L6, Canada"},{"name":"Department of Pathology, The University of Western Ontario, London, ON, Canada N6A 5C1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Chan-Seng-Yue","sequence":"additional","affiliation":[{"name":"Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, ON, Canada M5G 1L7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, Victoria Hospital, London Health Science Centre, Room B3-431A, 800 Commissioners Road East, London, ON, Canada N6A 5W9"},{"name":"London Regional Cancer Program, London, ON, Canada N6A 4L6"},{"name":"Department of Oncology, The University of Western Ontario, London, ON, N6A 4L6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, Victoria Hospital, London Health Science Centre, Room B3-431A, 800 Commissioners Road East, London, ON, Canada N6A 5W9"},{"name":"Lawson Health Research Institute, London, ON, Canada N6C 2R5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud H. 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