{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:01Z","timestamp":1788872281958,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Fruits of\n                    <jats:italic>Pterodon pubescens<\/jats:italic>\n                    Benth have been used traditionally for the treatment of rheumatism, sore throat, and respiratory disorders, and also as anti-inflammatory, analgesic, depurative, tonic, and hypoglycemic agent. The study was aimed at evaluating the anti-inflammatory activity of the hexane fraction of an ethanolic extract of\n                    <jats:italic>P. pubescens<\/jats:italic>\n                    fruits. The oil from\n                    <jats:italic>P. pubescens<\/jats:italic>\n                    fruits was extracted with ethanol and partitioned with hexane. The anti-inflammatory activity was measured with increasing doses of the hexane fraction (FHPp) by using a carrageenan-induced rat model of pleurisy and a rat model of complete Freund's adjuvant-induced arthritis by using an FHPp dose of 250\u2009mg\/kg for 21 days. Treatment with an FHPp resulted in anti-inflammatory activity in both models. The results of biochemical, hematological, and histological analyses indicated a significant decrease in glucose, cholesterol, and triglycerides levels (18.32%, 34.20%, and 41.70%, resp.) and reduction in the numbers of total leukocytes and mononuclear cells. The FHPp dose of 1000\u2009mg\/kg induced no changes in behavioral parameters, and no animal died. The results of this study extend the findings of previous reports that have shown that administration of extracts and fractions obtained from species of the genus\n                    <jats:italic>Pterodon<\/jats:italic>\n                    exhibits anti-inflammatory activity and lacks toxicity.\n                  <\/jats:p>","DOI":"10.1155\/2013\/272795","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T03:18:05Z","timestamp":1375672685000},"page":"1-7","source":"Crossref","is-referenced-by-count":13,"title":["Inhibitory Effect of the Hexane Fraction of the Ethanolic Extract of the Fruits of\n                    <i>Pterodon pubescens<\/i>\n                    Benth in Acute and Chronic Inflammation"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-9002","authenticated-orcid":true,"given":"Jaqueline","family":"Hoscheid","sequence":"first","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farm\u00e1cia, Avenida Colombo, 5790 bloco K80. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciomar Aparecida","family":"Bersani-Amado","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farmacologia e Terap\u00eautica, Avenida Colombo, 5790 bloco K68. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ambr\u00f3sio","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farmacologia e Terap\u00eautica, Avenida Colombo, 5790 bloco K68. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-6437","authenticated-orcid":true,"given":"Priscila Miyuki","family":"Outuki","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farm\u00e1cia, Avenida Colombo, 5790 bloco K80. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ang\u00e9lica Raffaini C\u00f3vas","family":"Pereira da Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farmacologia e Terap\u00eautica, Avenida Colombo, 5790 bloco K68. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Lacir","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1-PUCPR, Escola de Ci\u00eancias Agr\u00e1rias, Avenida da Uni\u00e3o, 500. Jardim Coopagro, 85902-532 Toledo, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara Lane Carvalho","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Centro de Ci\u00eancias da Sa\u00fade, Departamento de Farm\u00e1cia, Avenida Colombo, 5790 bloco K80. Zona Sete, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"605","volume":"46","year":"2010","journal-title":"Brazilian Journal of Pharmaceutical Sciences"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2008.2308.2313"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/S0102-695X2008000300023","volume":"18","year":"2008","journal-title":"Revista Brasileira De Farmacognosia"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0103-50532000000200015","volume":"11","year":"2000","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/S0102-695X2004000300017","volume":"14","year":"2004","journal-title":"Revista Brasileira De Farmacognosia"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00116-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1211\/0022357022485"},{"issue":"3","key":"8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/S0103-50532009000300024","volume":"20","year":"2009","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-10-1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.014"},{"key":"11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2012.06.020","volume":"143","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00288-4"},{"key":"13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/(SICI)1099-1573(199911)13:7<613::AID-PTR503>3.0.CO;2-D","volume":"13","year":"1999","journal-title":"Phytotherapy Research"},{"key":"14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.talanta.2012.07.094","volume":"100","year":"2012","journal-title":"Talanta"},{"issue":"9","key":"15","first-page":"2588","volume":"41","year":"1982","journal-title":"Federation Proceedings"},{"key":"16","first-page":"73","volume":"42","year":"1963","journal-title":"The American Journal of Pathology"},{"issue":"1","key":"17","first-page":"14","volume":"188","year":"1970","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"issue":"4","key":"18","first-page":"320","volume":"25","year":"1962","journal-title":"Lloydia"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10787-011-0081-9","volume":"19","year":"2011","journal-title":"Inflammopharmacology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00110-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021695625457"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2005.00346.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(93)90010-6"},{"key":"23","year":"1942"},{"key":"24","first-page":"1250","volume-title":"Natural production (secondary metabolites)","year":"2000"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957410"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2012.02.015"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-008-9098-7"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/272795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/272795.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/272795.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T13:21:38Z","timestamp":1498051298000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/272795\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":28,"alternative-id":["272795","272795"],"URL":"https:\/\/doi.org\/10.1155\/2013\/272795","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}