{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:29Z","timestamp":1787017709067,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    The study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM. The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy. The control group included 21 pediatric patients. We performed (1) S-cone ERG testing with retina response stimulation in both eyes at the luminance of 0.1, 0.2, and 0.5\u2009(cd \u00d7 s\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) with the 440\u2009nm blue flash and light application of the amber background (300\u2009ph\u2009cd\/m\n                    <jats:sup>2<\/jats:sup>\n                    , 495\u2009nm wavelength), (2) anthropometric measurements, (3) biochemical investigations: IL-17, VEGF, and ADM by the ELISA method. A comparison of the ERG results with biochemical investigations indicates a likely correlation between the worsening of retinal bioelectric function and VEGF levels growing with diabetes duration. We showed a negative correlation between ADM and HbA1c and described possible causes of ADM reduction observed in subgroup I. We demonstrated the presence of bioelectric retinal dysfunction already before the diagnosis of diabetic retinopathy, which provides new possibilities in the diagnosis of preclinical chronic complications of diabetes. The changes observed in the levels of IL-17, ADM, and VEGF suggest their involvement in the diabetic pathogenesis of eye diseases.\n                  <\/jats:p>","DOI":"10.1155\/2013\/274726","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T19:52:46Z","timestamp":1384804366000},"page":"1-8","source":"Crossref","is-referenced-by-count":18,"title":["Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-0481","authenticated-orcid":true,"given":"Kornel","family":"Semeran","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bia\u0142ystok, Ulica Waszyngtona 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ophthalmology with Strabismus Treatment Unit, Medical University of Bia\u0142ystok, Ulica Waszyngtona 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-1968","authenticated-orcid":true,"given":"\u0141ukasz","family":"Lisowski","sequence":"additional","affiliation":[{"name":"Scientific Circle at the Department of Pediatric Ophthalmology with Strabismus Treatment Unit, Medical University of Bia\u0142ystok, Ulica Waszyngtona 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Szczepaniak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bia\u0142ystok, Ulica 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