{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:31:17Z","timestamp":1791729077688,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome (SS) is a chronic slowly progressive autoimmune disorder characterized by symptoms of oral and ocular dryness, exocrine dysfunction, and lymphocytic infiltration of exocrine glands. Multiple myeloma (MM) is a bone-marrow-based malignant neoplasm of plasma cells associated with serum\/urine monoclonal paraproteins and lytic skeletal lesions. There have been very few reported cases of MM, who had SS as the first presentation. We report a case of a woman diagnosed with Sj\u00f6gren\u2019s syndrome, who was later suspected to have multiple myeloma on serum protein electrophoresis. Fluorescence<jats:italic>in situ<\/jats:italic>hybridization (FISH) was carried out to check for deletions of loci 13q14.3, ATM, p53, and IGH (14q32) rearrangements on a bone marrow aspirate. Monosomy 13 was observed in 49% of cells, and a rearrangement at the IGH locus was seen in 42% of cells. To determine the partner chromosome associated with the IGH rearrangement, further FISH tests were set up for t(4;14)(p16;q32) followed by t(14;16)(q32;q22) on fresh slides. The test was negative for t(4;14) but positive for t(14;16) in 27% of cells. This confirmed the diagnosis of MM. We report the first case from India, having an association of Sj\u00f6gren\u2019s syndrome with multiple myeloma, which showed t(14;16) and monosomy 13 by FISH analysis.<\/jats:p>","DOI":"10.1155\/2013\/279801","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T21:02:50Z","timestamp":1358370170000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Detection of t(14;16)(q32;q22) and Monosomy 13 by FISH Analysis in a Patient with Multiple Myeloma Associated with Sj\u00f6gren\u2019s Syndrome: The First Case Report from India"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-4654","authenticated-orcid":true,"given":"Rupesh R.","family":"Sanap","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-6226","authenticated-orcid":true,"given":"Arundhati S.","family":"Athalye","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-6345","authenticated-orcid":true,"given":"Prochi F.","family":"Madon","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-1408","authenticated-orcid":true,"given":"Boman N.","family":"Dhabhar","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-6312","authenticated-orcid":true,"given":"Mahendra B.","family":"Sute","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit A.","family":"Mahabale","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3681-130X","authenticated-orcid":true,"given":"Dhanashree J.","family":"Warang","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. Deshmukh Marg, Mumbai 400026, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firuza R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre, 15 Dr. G. 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