{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:53:45Z","timestamp":1761929625294,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["58283","CB-2009-01-129316","IN-214011-3"],"award-info":[{"award-number":["58283","CB-2009-01-129316","IN-214011-3"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["58283","CB-2009-01-129316","IN-214011-3"],"award-info":[{"award-number":["58283","CB-2009-01-129316","IN-214011-3"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Apoyo a Proyectos de Innovaci\u00f3n Tecnol\u00f3gica","award":["58283","CB-2009-01-129316","IN-214011-3"],"award-info":[{"award-number":["58283","CB-2009-01-129316","IN-214011-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Human neurocysticercosis by<jats:italic>Taenia solium<\/jats:italic>is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the<jats:italic>T. solium<\/jats:italic>adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans. Tamoxifen is an antiestrogenic drug with cysticidal action on<jats:italic>Taenia crassiceps<\/jats:italic>, a close relative of<jats:italic>T. solium<\/jats:italic>. Thus, we evaluated the effect of tamoxifen on the<jats:italic>in vitro<\/jats:italic>evagination and the<jats:italic>in vivo<\/jats:italic>establishment of<jats:italic>T. solium<\/jats:italic>.<jats:italic>In vitro<\/jats:italic>, tamoxifen inhibited evagination of<jats:italic>T. solium<\/jats:italic>cysticerci in a dose-time dependent manner.<jats:italic>In vivo<\/jats:italic>, administration of tamoxifen to hamsters decreased the intestinal establishment of the parasite by 70%, while recovered tapeworms showed an 80% reduction in length, appearing as scolices without strobilar development. Since tamoxifen did not show any significant effect on the proliferation of antigen-specific immune cells, intestinal inflammation, and expression of Th1\/Th2 cytokines in spleen and duodenum, this drug could exert its antiparasite actions by having direct detrimental effects upon the adult tapeworm. These results demonstrate that tamoxifen exhibits a strong cysticidal and antitaeniasic effect on<jats:italic>T. solium<\/jats:italic>that should be further explored in humans and livestock.<\/jats:p>","DOI":"10.1155\/2013\/280496","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T16:03:40Z","timestamp":1356019420000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by<i>Taenia solium<\/i>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Galileo","family":"Escobedo","sequence":"first","affiliation":[{"name":"Unidad de Medicina Experimental, Hospital General de M\u00e9xico, M\u00e9xico, DF 06726, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Isabel","family":"Palacios-Arreola","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, AP 70228, M\u00e9xico, DF 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Olivos","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Experimental, Hospital General de M\u00e9xico, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico, DF 06726, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"L\u00f3pez-Griego","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, AP 70228, M\u00e9xico, DF 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Morales-Montor","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, AP 70228, M\u00e9xico, DF 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70194-0"},{"issue":"3","key":"2","first-page":"116","volume":"20","year":"2005","journal-title":"Neurologia"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001500"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-917661"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00454-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238514.51747.3a"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X300788"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/157489211795328486"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-007-1567-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.05.009"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn509"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000249"},{"issue":"7","key":"13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1590\/S0074-02762010000700021","volume":"105","year":"2010","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"issue":"2","key":"14","first-page":"131","volume":"57","year":"1989","journal-title":"Acta Leidensia"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.05.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1191.1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01257.x"},{"issue":"9","key":"18","first-page":"926","volume":"114","year":"1990","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2009.07.007"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/591079"},{"issue":"9","key":"21","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.7150\/ijbs.7.1443","volume":"7","year":"2011","journal-title":"International Journal of Biological Sciences"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1645\/GE-779R1.1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1018R1.1"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00063-7"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(96)00095-3"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0490"},{"issue":"4","key":"27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2307\/3283192","volume":"80","year":"1994","journal-title":"Journal of Parasitology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2010.01.016"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939589"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1428.079"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.020"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.09.013"},{"issue":"5","key":"33","first-page":"1132","volume":"87","year":"2001","journal-title":"Journal of Parasitology"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00152-8"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)00373-X"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/280496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/280496.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/280496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:35:18Z","timestamp":1498005318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2013\/280496\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":35,"alternative-id":["280496","280496"],"URL":"https:\/\/doi.org\/10.1155\/2013\/280496","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2013]]}}}