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Experimental model of ischemic AKI was induced in rats by bilateral renal artery clamp for 45\u2009min followed by reperfusion of 12\u2009h and 24\u2009h, respectively. AS-IV was orally administered once a day to rats at 10 and 20\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7d<jats:sup>\u22121<\/jats:sup>for 7 days prior to ischemia. AS-IV pretreatment significantly decreased serum urea, creatinine, and cystatin C levels at 12\u2009h and 24\u2009h of reperfusion in AKI rats. AS-IV pretreatment also ameliorated tubular damage and suppressed the phosphorylation of p65 subunit of NF-<jats:italic>\u03ba<\/jats:italic>B in AKI rats. Moreover, NF-<jats:italic>\u03ba<\/jats:italic>B and MPO activity as well as serum and tissue levels of TNF-<jats:italic>\u03b1<\/jats:italic>, MCP-1, and ICAM-1 were elevated in AKI rats. All of these abnormalities were prevented by AS-IV. Furthermore, AS-IV downregulated the mRNA expression of NF-<jats:italic>\u03ba<\/jats:italic>B, TNF-<jats:italic>\u03b1<\/jats:italic>, MCP-1, and ICAM-1 in AKI rats. These results suggest that AS-IV might be developed as a novel therapeutic approach to prevent ischemic AKI through inhibition of NF-<jats:italic>\u03ba<\/jats:italic>B mediated inflammatory genes expression.<\/jats:p>","DOI":"10.1155\/2013\/284025","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T17:03:47Z","timestamp":1371661427000},"page":"1-12","source":"Crossref","is-referenced-by-count":23,"title":["Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats"],"prefix":"10.1155","volume":"2013","author":[{"given":"Shufeng","family":"Tan","sequence":"first","affiliation":[{"name":"Health Examination Center, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofu","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Lab of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingkun","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.275.19.1489"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090740"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010877"},{"issue":"22","key":"4","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199605303342207","volume":"334","year":"1996","journal-title":"The New England Journal of Medicine"},{"issue":"5","key":"5","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/ki.1997.200","volume":"51","year":"1997","journal-title":"Kidney International"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200007000-00015"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.151860b"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.761_2.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.761_3.x"},{"issue":"91","key":"10","first-page":"S56","volume":"66","year":"2004","journal-title":"Kidney International. 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