{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:39:57Z","timestamp":1753886397190,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":261,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10. <jats:italic>Methods<\/jats:italic>. 66 Blood samples (2% creatine monohydrate supplemented (<jats:italic>N<\/jats:italic> = 34) and unsupplemented (<jats:italic>N<\/jats:italic> = 32)) were analyzed for various hematological (blood glucose, packed cell volume, total WBC count, total RBC count) and serum biochemical parameters (cholesterol, AST, ALT, HDL, LDL, total protein, triglycerides). <jats:italic>Results<\/jats:italic>. ALT had higher concentrations in mice feeding on normal diet for 8 (<jats:italic>P<\/jats:italic> &gt; 0.01) and 12 weeks (<jats:italic>P<\/jats:italic> &gt; 0.01) following asphyxia and in 12 weeks treatment without asphyxia (<jats:italic>P<\/jats:italic> = 0.006) when compared with the creatine supplemented mice. LDL (<jats:italic>P<\/jats:italic> = 0.011) and cholesterol (<jats:italic>P<\/jats:italic> &gt; 0.01) had higher concentrations in mice on normal diet for 12 weeks following hypoxia ischemia. Cholesterol (<jats:italic>P<\/jats:italic> &gt; 0.01) in 12 and glucose (<jats:italic>P<\/jats:italic> = 0.006) in 15 week treatment group had significantly lower concentrations in creatine supplemented male albino mice when compared with untreated group following hxpoic\u2010ischemic insult. <jats:italic>Conclusion<\/jats:italic>. We concluded that creatine supplementation following hypoxic ischemic insult helps in maintain the normal blood chemistry.<\/jats:p>","DOI":"10.1155\/2013\/286075","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:43:26Z","timestamp":1379637806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia\u2010Ischemia Encephalopathy"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-1514","authenticated-orcid":false,"given":"Shahid","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabia","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quratulane","family":"Gillani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-0152","authenticated-orcid":false,"given":"Furhan","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.047985"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161207781368611"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-010-1022-0"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.12.002"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S3361"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22419"},{"key":"e_1_2_9_7_2","first-page":"341","article-title":"Pattern of admission to neonatal unit","volume":"15","author":"Parkash J.","year":"2005","journal-title":"Journal of the College of Physicians and Surgeons Pakistan"},{"key":"e_1_2_9_8_2","first-page":"231","article-title":"Priorities in newborn care and development of clinical neonatology in Pakistan: where to now?","volume":"7","author":"Bhutta Z. 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