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In B cells, PRL enhances antibody production, including antibodies with self-specificity. In this study, our aims were to determine the level of PRL receptor expression during bone-marrow B-cell development and to assess whether the presence of high PRL serum concentrations influences absolute numbers of developing populations and disease outcome in lupus-prone murine models. We observed that the PRL-receptor is expressed in early bone-marrow B-cell; the expression in lupus-prone mice, which had the highest level of expression in pro-B cells and immature cells, differed from that in wild-type mice. These expression levels did not significantly change in response to hyperprolactinemia; however, populations of pro-B and immature cells from lupus-prone strains showed a decrease in the absolute numbers of cells with high PRL-receptor expression in response to PRL. Because immature self-reactive B cells are constantly being eliminated, we assessed the expression of survival factor BIRC5, which is more highly expressed in both pro-B and immature B-cells in response to PRL and correlates with the onset of disease. These results identify an important role of PRL in the early stages of the B-cell maturation process: PRL may promote the survival of self-reactive clones.<\/jats:p>","DOI":"10.1155\/2013\/287469","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T16:04:54Z","timestamp":1384877094000},"page":"1-11","source":"Crossref","is-referenced-by-count":30,"title":["Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL\/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease"],"prefix":"10.1155","volume":"2013","author":[{"given":"Maria Victoria","family":"Legorreta-Haquet","sequence":"first","affiliation":[{"name":"UIM en Inmunolog\u00eda, Hospital de Pediatr\u00eda, CMN Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Flores-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"UIM en Inmunolog\u00eda, Hospital de Pediatr\u00eda, CMN Siglo XXI, 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