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Nineteen patients were included and treated with IFX 5\u2009mg\/kg every 6 weeks for 56 weeks. All patients concomitantly received MTX with median dose 7.5\u2009mg\/weekly. During the second year, the IFX dose was reduced to 3\u2009mg\/kg every 8 weeks. Eighteen patients completed the 1-year and 15 patients the 2-year trial. The \u226550% improvement at week 16 from baseline of BASDAI was achieved in 16\/19 (84%) patients. Significant reductions in BASDAI, BASFI, and BASMI scores, decrease in ESR and CRP, and improvement in SF-36 were observed at weeks 16 and 56. The MRI-defined inflammatory changes in the sacroiliac joints disappeared in 10\/15 patients (67%) already at 16 weeks. IFX treatment effect was sustained throughout the second year after IFX dose reduction and interval extension. We conclude that IFX treatment is effective in well-established active AS and a dose reduction sustains the treatment effect. These observations are of clinical importance and open the opportunity to reduce the drug costs. 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