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Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy.\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties. The object of this study was to investigate the effects of\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    on the prevention of post-laminectomy EF formation in a rat model. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1)\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    treatment group, (2) saline treatment group, and (3) sham group (laminectomy without treatment). All rats were euthanized humanely 4 weeks after laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    group than the other two groups. Topical application of\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    could inhibit fibroblasts proliferation and TGF-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model.\n                  <\/jats:p>","DOI":"10.1155\/2013\/291814","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T17:01:06Z","timestamp":1377795666000},"page":"1-7","source":"Crossref","is-referenced-by-count":24,"title":["An Experimental Novel Study:\n                    <i>Angelica sinensis<\/i>\n                    Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-\n                    <i>\u03b2<\/i>\n                    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