{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:20:56Z","timestamp":1762017656471},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,6,23]],"date-time":"2013-06-23T00:00:00Z","timestamp":1371945600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Cardiology"],"published-print":{"date-parts":[[2013,6,23]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> The objective of this study was to determine the frequency of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) with an isolated, large left-to-right shunt and to indicate the factors in the development of PAH. <jats:italic>Methods.<\/jats:italic> The pressure measurements in the cardiac chambers and the calculations based on the Fick\u2019s principle were compared among 3 separate groups of patients, respectively, with PAH, with hyperkinetic pulmonary hypertension (HPH), and with neither PAH nor HPH. <jats:italic>Results.<\/jats:italic> PAH was diagnosed in 30 (12.3%) patients, HPH in 35 (14.4%), while 177 (73.1%) were free of either. The highest risk for the development of PAH was found in the presence of perimembranous ventricular septal defect. A statistically significant difference was seen among these groups as to their left atrial pressure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>) and the mean pulmonary arterial pressure (PAP<jats:sub>mean<\/jats:sub>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). While a correlation was present between RpI on one hand and age on the other (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.014<\/mml:mn><\/mml:math>), a multiple linear regression could not evidence any correlation among age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.321<\/mml:mn><\/mml:math>), gender (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.929<\/mml:mn><\/mml:math>). <jats:italic>Conclusion.<\/jats:italic> Our findings do not allow establishing a correlation between the duration of the high pulmonary flow and pulmonary vascular resistance increase or PAH development in isolated left-to-right shunts with congenital heart diseases.<\/jats:p>","DOI":"10.1155\/2013\/301617","type":"journal-article","created":{"date-parts":[[2013,6,23]],"date-time":"2013-06-23T21:00:55Z","timestamp":1372021255000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Left-to-Right Shunt with Congenital Heart Disease: Single Center Experience"],"prefix":"10.1155","volume":"2013","author":[{"given":"Ayhan","family":"Cevik","sequence":"first","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Olgunturk","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Kula","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"Saylan","sequence":"additional","affiliation":[{"name":"D\u0131skap\u0131 Children's Hospital Department of Pediatric Cardiology, 06110 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayhan","family":"Pektas","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Oguz","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedef","family":"Tunaoglu","sequence":"additional","affiliation":[{"name":"Gazi University Medical Faculty Hospital, Department of Pediatric Cardiology, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109990138"},{"issue":"2","key":"2","first-page":"273","volume":"23","year":"2004","journal-title":"Revista Portuguesa de Cardiologia"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109990771"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21446"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0920-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007910"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.195248"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.09.017"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868080-00004"},{"key":"14","first-page":"1147","volume-title":"Pulmonary vascular 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