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The aim of this study was to investigate the nutritive composition and antioxidant potential and anti-inflammatory effects of<jats:italic>A. rugosum<\/jats:italic>extracts on LPS-stimulated RAW264.7 cells. Nutritional analysis of freeze-dried mycelia of<jats:italic>A. rugosum<\/jats:italic>(KUM 61131) from submerged culture indicated a predominant presence of carbohydrates, proteins, dietary fibre, phosphorus, potassium, and sodium. The ethanol crude extract (EE), its hexane (HF), ethyl acetate (EAF), and aqueous (AF) fractions of mycelia of<jats:italic>A. rugosum<\/jats:italic>grown in submerged culture were evaluated for antioxidant potential and anti-inflammatory effects. EAF exhibited the highest total phenolic content and the strongest antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. HF showed dose-dependent inhibition of NO production in LPS-stimulated RAW264.7 cells and NO radical scavenging activity. Gas chromatographic analysis of HF revealed the presence of ethyl linoleate and ergosterol, compounds with known anti-inflammatory properties. In conclusion, the nutritive compositions and significant antioxidant potential and anti-inflammatory effects of mycelia extracts of<jats:italic>A. rugosum<\/jats:italic>have the potential to serve as a therapeutic agent or adjuvant in the management of inflammatory disorders.<\/jats:p>","DOI":"10.1155\/2013\/304713","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T23:58:45Z","timestamp":1385423925000},"page":"1-10","source":"Crossref","is-referenced-by-count":29,"title":["<i>Amauroderma rugosum<\/i>(Blume &amp; T. 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