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Much evidence confirms that angiotensin II is directly involved in NAD(P)H oxidase activation and consequent superoxide anion production, which can damage DNA. The current study was performed to examine the effects of angiotensin\u2010II\u2010dependent hypertension in bone marrow mononuclear cells (BM\u2010MNC); dihydroethidium staining was used to assess reactive oxygen species (ROS) production, and the comet assay was used to assess DNA fragmentation in 2K1C hypertensive mice 14 days after renal artery clipping. In this study we demonstrated that 2K1C hypertensive mice have an elevated lymphocyte count, while undifferentiated BM\u2010MNC counts were diminished. 2K1C mice also showed an augmented ROS production and marked BM\u2010MNC DNA fragmentation. In conclusion, endogenous renin angiotensin system activation\u2010induced arterial hypertension is characterized by excessive ROS production in BM\u2010MNC, which might cause marked DNA damage.<\/jats:p>","DOI":"10.1155\/2013\/305202","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T16:08:17Z","timestamp":1360858097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["DNA Damage and Augmented Oxidative Stress in  Bone Marrow Mononuclear Cells from Angiotensin\u2010Dependent Hypertensive Mice"],"prefix":"10.1155","volume":"2013","author":[{"given":"Bianca P.","family":"Campagnaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa L.","family":"Tonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno V.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce E.","family":"Casarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisardo C.","family":"Vasquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana S.","family":"Meyrelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/236239"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337595"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-044"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-067"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.06.005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117886"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010713"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.100589"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04998.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.006965"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046067"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00678.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00278-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f09f79"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020149"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1337"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1597"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004000800018"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn230"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715760903494168"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1310"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6196"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000182154.61862.52"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/968123"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90265-0"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(1997)30:2<139::AID-EM6>3.0.CO;2-I"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00015-7"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.4.1025"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.3.503"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000164571.77710.19"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000140892.86313.c2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282fe6eaa"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(03)00135-2"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00224.2006"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.10.001"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.02.020"},{"key":"e_1_2_6_37_2","first-page":"4","article-title":"Vascular renin-angiotensin system in hypertension. 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