{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:21:16Z","timestamp":1789993276532,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2009-0067980"],"award-info":[{"award-number":["2009-0067980"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2010-0004959"],"award-info":[{"award-number":["2010-0004959"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2009-0067980"],"award-info":[{"award-number":["2009-0067980"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2010-0004959"],"award-info":[{"award-number":["2010-0004959"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-amyloid peptide (A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>), a major component of senile plaques, plays important roles in neuropathology of Alzheimer's disease (AD). An array of<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>data indicates that A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-induced neuronal death is mediated by oxidative stress. In this study, we aimed to investigate effects of sulforaphane (SUL), an isothiocyanate in cruciferous vegetables, on A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-induced oxidative cell death in SH-SY5Y cells. Cells treated with A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>25<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn>35<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>exhibited decreased cell viability and underwent apoptosis as determined by MTT assay and TUNEL, respectively. A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>25<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn>35<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-induced cytotoxicity and apoptotic characteristics such as activation of c-JNK, dissipation of mitochondrial membrane potential, altered expression of Bcl-2 family proteins, and DNA fragmentation were effectively attenuated by SUL pretreatment. The antiapoptotic activity of SUL seemed to be mediated by inhibition of intracellular accumulation of reactive oxygen species and oxidative damages. SUL exerted antioxidant potential by upregulating expression of antioxidant enzymes including<jats:italic>\u03b3<\/jats:italic>-glutamylcysteine ligase, NAD(P)H:quinone oxidoreductase-1, and heme oxygenase-1 via activation of NF-E2-related factor 2(Nrf2). The protective effect of SUL against A<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>25<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn>35<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-induced apoptotic cell death was abolished by siRNA of Nrf2. Taken together, the results suggest that pharmacologic activation of Nrf2 signaling pathway by SUL might be a practical prevention and\/or protective treatment for the management of AD.<\/jats:p>","DOI":"10.1155\/2013\/313510","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T17:19:54Z","timestamp":1371748794000},"page":"1-12","source":"Crossref","is-referenced-by-count":79,"title":["Attenuation of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"bold-italic\">\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2"],"prefix":"10.1155","volume":"2013","author":[{"given":"Chan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Keimyung University, Daegu 704-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu 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