{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:28:21Z","timestamp":1784651301383,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Based on the collected ethnobotanical data from the Traditional Medicine and Materia Medica Research Center (TMRC), Iran,<jats:italic>Myrtus communis<\/jats:italic>L. (myrtle) was selected for the assessment of<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>antimalarial and cytotoxic activities. Methanolic extract of myrtle was prepared from the aerial parts and assessed for antiplasmodial activity, using the parasite lactate dehydrogenase (pLDH) assay against chloroquine-resistant (K1) and chloroquine-sensitive (3D7) strains of<jats:italic>Plasmodium falciparum<\/jats:italic>. The 4-day suppressive test was employed to determine the parasitemia suppression of the myrtle extract against<jats:italic>P. berghei<\/jats:italic>\u2009\u2009<jats:italic>in vivo<\/jats:italic>. The IC<jats:sub>50<\/jats:sub>values of myrtle extract were 35.44\u2009\u00b5g\/ml against K1 and 0.87\u2009\u00b5g\/ml against 3D7. Myrtle extract showed a significant suppression of parasitaemia (84.8 \u00b1 1.1% at 10\u2009mg\/kg\/day) in mice infected with<jats:italic>P. berghei<\/jats:italic>after 4 days of treatment. Cytotoxic activity was carried out against mammalian cell lines using methyl thiazol tetrazolium (MTT) assay. No cytotoxic effect on mammalian cell lines up to 100\u2009\u00b5g\/mL was shown. The results support the traditional use of myrtle in malaria. Phytochemical investigation and understanding the mechanism of action would be in our upcoming project.<\/jats:p>","DOI":"10.1155\/2013\/316185","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T16:00:55Z","timestamp":1387814455000},"page":"1-5","source":"Crossref","is-referenced-by-count":18,"title":["<i>In Vitro<\/i>and<i>In Vivo<\/i>Antimalarial Evaluations of Myrtle Extract, a Plant Traditionally Used for Treatment of Parasitic Disorders"],"prefix":"10.1155","volume":"2013","author":[{"given":"Farzaneh","family":"Naghibi","sequence":"first","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6354, Tehran 1516745811, Iran"},{"name":"School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6354, Tehran 1516745811, Iran"},{"name":"School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Rain","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Center, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Nateghpour","sequence":"additional","affiliation":[{"name":"School of Public Health, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Taghvai","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6354, Tehran 1516745811, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Kamkar","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6354, Tehran 1516745811, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mosaddegh","sequence":"additional","affiliation":[{"name":"Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, P.O. Box 14155-6354, Tehran 1516745811, Iran"},{"name":"School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"9","key":"1","first-page":"1314","volume":"85","year":"2003","journal-title":"Current Science"},{"key":"2","year":"2011"},{"key":"3","first-page":"1","volume":"1","year":"2006","journal-title":"Iranian Journal of Parasitology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.04.017"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.12.011"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00141-7"},{"key":"7","first-page":"63","volume":"2","year":"2005","journal-title":"Iranian Journal of Pharmaceutical Research"},{"issue":"4","key":"8","first-page":"395","volume":"2","year":"2011","journal-title":"Indian Journal of Natural Products and Resources"},{"issue":"4254","key":"9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","year":"1976","journal-title":"Science"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4269\/ajtmh.1993.48.205","volume":"48","year":"1993","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.02.025"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/00034983.1975.11686997","volume":"69","year":"1975","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.10.041"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.004"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/10412905.1997.10554252","volume":"9","year":"1997","journal-title":"Journal of Essential Oil Research"},{"key":"16","year":"1998"},{"key":"17","year":"2011"},{"key":"18","volume-title":"Guidelines for the nonclinical evaluation of the efficacy of traditional antimalarials","year":"2004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.01.026"},{"issue":"2","key":"20","first-page":"17","volume":"4","year":"2010","journal-title":"Journal of Herbal Medicine and Toxicology"},{"issue":"23","key":"21","first-page":"6612","volume":"8","year":"2009","journal-title":"African Journal of Biotechnology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.11.009"},{"issue":"1","key":"23","first-page":"137","volume":"3","year":"2006","journal-title":"African Journal of Traditional, Complementary and Alternative Medicines"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1080\/00034980020035915"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00073-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1080\/13880200701214748"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-1-26"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1021\/jm0600545"},{"issue":"9","key":"31","first-page":"726","volume":"4","year":"2010","journal-title":"Journal of Medicinal Plant Research"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14083037"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/316185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/316185.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/316185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:50:53Z","timestamp":1498092653000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/316185\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":30,"alternative-id":["316185","316185"],"URL":"https:\/\/doi.org\/10.1155\/2013\/316185","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}