{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:17:49Z","timestamp":1740140269537,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["200907001-4"],"award-info":[{"award-number":["200907001-4"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic. However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy.<jats:italic>Methods<\/jats:italic>. 230 patients were randomly assigned to 7\u201310 days of Andrographolide Sulfonate 5\u201310\u2009mg\/Kg\/day and conventional therapy, or conventional therapy alone.<jats:italic>Results<\/jats:italic>. The major complications occurred less often after Andrographolide Sulfonate (2.6% versus 12.1%; risk difference [RD], 0.94; 95% CI, 0.28\u20131.61;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mtext>0<\/mml:mtext><mml:mtext>.006<\/mml:mtext><\/mml:math>). Median fever clearance times were 96 hours (CI, 80 to 126) for conventional therapy recipients and 48 hours (CI, 36 to 54) for Andrographolide Sulfonate combination-treated patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msup><mml:mi>\u03c7<\/mml:mi><mml:mtext>2<\/mml:mtext><\/mml:msup><mml:mo>=<\/mml:mo><mml:mtext>16<\/mml:mtext><mml:mtext>.57<\/mml:mtext><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The two groups did not differ in terms of HFMD-cause mortality (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mtext>1<\/mml:mtext><mml:mtext>.00<\/mml:mtext><\/mml:math>) and duration of hospitalization (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mtext>0<\/mml:mtext><mml:mtext>.70<\/mml:mtext><\/mml:math>). There was one death in conventional therapy group. No important adverse event was found in Andrographolide Sulfonate combination therapy group.<jats:italic>Conclusions<\/jats:italic>. The addition of Andrographolide Sulfonate to conventional therapy reduced the occurrence of major complications, fever clearance time, and the healing time of typical skin or oral mucosa lesions in children with severe HFMD.<\/jats:p>","DOI":"10.1155\/2013\/316250","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T16:07:37Z","timestamp":1358266057000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2013","author":[{"given":"Xiuhui","family":"Li","sequence":"first","affiliation":[{"name":"You\u2019an Hospital, Capital Medical University, Beijing, Fengtai 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese 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