{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:29:47Z","timestamp":1788838187781,"version":"build-2803163510"},"reference-count":37,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Effect of methanolic extract of<jats:italic>Rumex hastatus<\/jats:italic>roots (MRR) and its derived fractions, n-hexane (HRR), ethyl acetate (ERR), chloroform (CRR), butanol (BRR), and aqueous extract (ARR), was studied against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) induced hepato and testicular toxicity in rats. Intraperitoneal dose of 20 percent CCl<jats:sub>4<\/jats:sub>(0.5 ml\/kg bw) was administered twice a week for eight weeks to a group of rats. Other groups were given CCl<jats:sub>4<\/jats:sub>and various fractions of<jats:italic>R. hastatus<\/jats:italic>roots (200\u2009mg\/kg bw). CCl<jats:sub>4<\/jats:sub>treatment depleted glutathione contents and activities of antioxidant enzymes while increased the concentration of lipid peroxides (TBARS) along with corresponding DNA injuries and histopathological damages. Supplementation with various fractions of<jats:italic>R. hastatus<\/jats:italic>roots (200\u2009mg\/kg body weight) attenuated the toxicity of CCl<jats:sub>4<\/jats:sub>in liver and testis tissues through improvement in the serological, enzymatic, and histological parameters towards the normal. Posttreatment of<jats:italic>R. hastatus<\/jats:italic>roots (200\u2009mg\/kg body weight) also reversed the alteration in reproductive hormonal secretions and DNA damages in CCl<jats:sub>4<\/jats:sub>treated rats. The results clearly demonstrated that<jats:italic>R. hastatus<\/jats:italic>treatment augments the antioxidants defense mechanism and provides the evidence that it may have a therapeutic role in free radical mediated diseases.<\/jats:p>","DOI":"10.1155\/2013\/325406","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T21:02:40Z","timestamp":1368565360000},"page":"1-11","source":"Crossref","is-referenced-by-count":28,"title":["Ameliorating Effect of Various Fractions of<i>Rumex hastatus<\/i>Roots against Hepato- and Testicular Toxicity Caused by CCl<sub>4<\/sub>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Sumaira","family":"Sahreen","sequence":"first","affiliation":[{"name":"Botanical Sciences Division, Pakistan Museum of Natural History, Garden Avenue, Shakarparian, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad 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