{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T06:38:00Z","timestamp":1772347080764,"version":"3.50.1"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Soft Science project of Anhui Province","award":["12020503084"],"award-info":[{"award-number":["12020503084"]}]},{"name":"Soft Science project of Anhui Province","award":["12YJA630121"],"award-info":[{"award-number":["12YJA630121"]}]},{"name":"Humanities and Social Sciences project of the Ministry of Education","award":["12020503084"],"award-info":[{"award-number":["12020503084"]}]},{"name":"Humanities and Social Sciences project of the Ministry of Education","award":["12YJA630121"],"award-info":[{"award-number":["12YJA630121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Randomized controlled trials (RCTs) have been conducted comparing the efficacy of rabeprazole 20\u2009mg or omeprazole 20\u2009mg once daily for patients with erosive gastroesophageal reflux disease (GERD). Until now, no study has synthesized all available data examining this issue.<jats:italic>Method<\/jats:italic>. Medline, Embase, and the Cochrane central register of controlled trials were searched (through December 2012). Eligible RCTs recruited adults with erosive GERD and reported endoscopic and symptomatic relief rates at the last point of follow-up. The effect of rabeprazole versus omeprazole was reported as relative risk (RR) of relief with a 95% confidence interval (CI).<jats:italic>Results<\/jats:italic>. The search identified 605 citations, and six RCTs containing 1,895 patients were eligible. Endoscopic relief rates were not significantly different between rabeprazole 20\u2009mg and omeprazole 20\u2009mg in treatment trials of up to 8 weeks. Heartburn relief rates were significantly different between the two groups for 8-week treatment trials. Adverse events were not significantly different between the two groups for 8-week treatment trials.<jats:italic>Conclusion<\/jats:italic>. These data suggest that rabeprazole demonstrates a clinical advantage over omeprazole in symptomatic relief but no significant difference in endoscopic relief of erosive GERD for up to 8 weeks of treatment. Rabeprazole and omeprazole were both tolerated by GERD patients.<\/jats:p>","DOI":"10.1155\/2013\/327571","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T21:43:28Z","timestamp":1378763008000},"page":"1-6","source":"Crossref","is-referenced-by-count":12,"title":["Gastroesophageal Reflux Disease Relief in Patients Treated with Rabeprazole 20<i>\u2009<\/i>mg versus Omeprazole 20<i>\u2009<\/i>mg: A Meta-Analysis"],"prefix":"10.1155","volume":"2013","author":[{"given":"X. M.","family":"Xia","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03708.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01999.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00884.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)01027-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80087-4"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0016-5085(00)70135-1","volume":"118","year":"2000","journal-title":"Gastroenterology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00438.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2.4.509"},{"issue":"5","key":"9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1046\/j.1365-2036.1997.00244.x","volume":"11","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00418.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855020-00009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/003655200453566"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03190.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.04.026"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600615781"},{"issue":"33","key":"16","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.3748\/wjg.v13.i33.4467","volume":"13","year":"2007","journal-title":"World Journal of Gastroenterology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.013"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018822532736"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9062-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9071-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90201-Y"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020124"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/327571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/327571.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2013\/327571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T21:37:24Z","timestamp":1498081044000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2013\/327571\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"alternative-id":["327571","327571"],"URL":"https:\/\/doi.org\/10.1155\/2013\/327571","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}