{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:26:24Z","timestamp":1791307584406,"version":"4.3.1"},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. According to the Consensus 2010 of the International Liaison Committee on Resuscitation (ILCOR), children with moderate to severe hypoxic-ischemic encephalopathy (HIE) should receive brain hypothermic therapy (BHT) after successful resuscitation. Elevated high mobility group box 1 (HMGB1) in the blood at the early stage of brain ischemia-reperfusion injury has been suggested to be involved in the release of various inflammatory cytokines.<jats:italic>Methods<\/jats:italic>. In total, 21 neonates plasma HMGB1 concentration was measured. These neonates included 8 with HIE in whom BHT was indicated, 5 controls diagnosed as having HIE but who were not suitable candidates for BHT, and 8 normal controls.<jats:italic>Results<\/jats:italic>. The umbilical artery HMGB1 (UA-HMGB1) level before undergoing BHT significantly exceeded reference values. The UA-HMGB1 level in the BHT (\u2212) group did not differ significantly from reference values, but was significantly increased 24 hours after birth. Repeated measure ANOVA showed a significant difference in time course changes between the BHT (+) and BHT (\u2212) groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0002<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. This study demonstrated hypothermic therapy to significantly decrease HMGB1. Furthermore, HMGB1 is a useful index of the inhibition of early stage inflammation.<\/jats:p>","DOI":"10.1155\/2013\/327604","type":"journal-article","created":{"date-parts":[[2013,9,22]],"date-time":"2013-09-22T17:05:47Z","timestamp":1379869547000},"page":"327-330","source":"Crossref","is-referenced-by-count":22,"title":["Brain Hypothermic Therapy Dramatically Decreases Elevated Blood Concentrations of High Mobility Group Box 1 in Neonates with Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1155","volume":"35","author":[{"given":"Toshihiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"National Hospital Organization, Nishisaitama-Chuo National Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Central Institute, Shino-Test Corporation, 2-29-14 Oonodai Minami-Ku, Sagamihara-Shi, Kanagawa-Ken 252-0331, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshirou","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Nishisaitama-Chuo National Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1432-1033.1973.tb03026.x","volume":"38","year":"1973","journal-title":"European Journal of Biochemistry"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.248"},{"issue":"6894","key":"3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","volume":"418","year":"2002","journal-title":"Nature"},{"issue":"10","key":"4","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1164\/ajrccm.164.10.2106117","volume":"164","year":"2001","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2003.01302.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2106117"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/cc5715","volume":"11","year":"2007","journal-title":"Critical Care"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000155991.88802.4D"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.04.016"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000209540.99176.72"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-05-0316"},{"key":"12","first-page":"245","volume-title":"Hypoxic-ischemic encephalopathy","year":"2008"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.035"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1159\/000116635"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04788.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600582"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03643.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-74"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2013\/327604.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2013\/327604.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2013\/327604.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T18:21:40Z","timestamp":1498069300000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2013\/327604\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"alternative-id":["327604","327604"],"URL":"https:\/\/doi.org\/10.1155\/2013\/327604","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}