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The changes in mice liver infected with HPAI H5N1 virus A\/goose\/Krasnoozerskoye\/627\/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-<jats:italic>\u03b1<\/jats:italic>, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. 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