{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:57:53Z","timestamp":1772740673822,"version":"3.50.1"},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Science and Technology Development Project of Nanjing","award":["201001090"],"award-info":[{"award-number":["201001090"]}]},{"name":"Science and Technology Development Project of Nanjing","award":["YKK10046"],"award-info":[{"award-number":["YKK10046"]}]},{"name":"Medical Science and Technology Development Project of Nanjing Health Bureau","award":["201001090"],"award-info":[{"award-number":["201001090"]}]},{"name":"Medical Science and Technology Development Project of Nanjing Health Bureau","award":["YKK10046"],"award-info":[{"award-number":["YKK10046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To reveal the effect of microRNA-210 on cell apoptosis caused by HIE.<jats:italic>Methods<\/jats:italic>. Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72\u2009h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-210 was identified by quantitative real-time PCR analysis. Apoptosis in brain sections was investigated by TUNEL assay. Apoptosis-related protein expressions were studied by Western blot analysis.<jats:italic>Results<\/jats:italic>. The results showed that microRNA-210, whose expression was downregulated in the brain 72\u2009h after HI injury, suppressed neuronal apoptosis by inhibiting caspase activity and regulating the balance between bcl-2 and bax levels.<jats:italic>Discussion<\/jats:italic>. Recent study demonstrated that microRNA-210 has neuroprotective effects through inhibiting apoptosis in a murine model of HIE. It represents a potential novel therapeutic approach for the treatment of HIE.<\/jats:p>","DOI":"10.1155\/2013\/350419","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T21:43:41Z","timestamp":1378763021000},"page":"1-5","source":"Crossref","is-referenced-by-count":32,"title":["Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1155","volume":"2013","author":[{"given":"Jie","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-guang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Newborn Infants, Nanjing Children\u2019s Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00398.x"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4161\/cc.9.6.11006","volume":"9","year":"2010","journal-title":"Cell Cycle"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1755"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.500736"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.186"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800731200"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.1167"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302654"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.12.031"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928424"},{"issue":"12","key":"11","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.STR.29.12.2622","volume":"29","year":"1998","journal-title":"Stroke"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/cbt.7.2.5297","volume":"7","year":"2008","journal-title":"Cancer Biology and Therapy"},{"key":"13","first-page":"1265","volume":"3","year":"2011","journal-title":"Frontiers in Bioscience"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000200799.64038.19"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.08.020"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01395-06"},{"key":"17","first-page":"21","volume":"66","year":"1996","journal-title":"Acta Neurochirurgica, Supplement"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.7.1103"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.03.008"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/350419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/350419.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/350419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T21:37:24Z","timestamp":1498081044000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/350419\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":19,"alternative-id":["350419","350419"],"URL":"https:\/\/doi.org\/10.1155\/2013\/350419","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}