{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:14:31Z","timestamp":1788869671321,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["2012KT1301"],"award-info":[{"award-number":["2012KT1301"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    . To explore whether\n                    <jats:italic>Astragalus<\/jats:italic>\n                    or its formulations could prevent upper respiratory infection in children with nephrotic syndrome and how best to use it.\n                    <jats:italic>Methods<\/jats:italic>\n                    . We transformed a common clinical question in practice to an answerable question according to the PICO principle. Databases, including the Cochrane Library (Issue 5, 2012), PUBMED (1966\u20132012.8), CBM (1978\u20132012.8), VIP (1989\u20132012.8), and CNKI (1979\u20132012.8), were searched to identify Cochrane systematic reviews and clinical trials. Then, the quality of and recommendations from the clinical evidence were evaluated using the GRADEpro software.\n                    <jats:italic>Results<\/jats:italic>\n                    . The search yielded 537 papers. Only two studies with high validity were included for synthesis calculations. The results showed that\n                    <jats:italic>Astragalus<\/jats:italic>\n                    granules could effectively reduce URTI in children with nephrotic syndrome compared with prednisone treatment alone (23.9% versus 42.9%; RR = 0.56 and 95% CI = 0.33\u20130.93). The dose of\n                    <jats:italic>Astragalus<\/jats:italic>\n                    granules was 2.25 gram (equivalent to 15 gram crude\n                    <jats:italic>Astragalus<\/jats:italic>\n                    ) twice per day, at least for 3\u20136 months. The level of evidence quality was low, but we still recommended the evidence to the patient according to GRADEpro with the opinion of the expert. Followup showed the incidence of URTI in this child decreased significantly.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    .\n                    <jats:italic>Astragalus<\/jats:italic>\n                    granules may reduce the incidence of URTI in children with nephrotic syndrome.\n                  <\/jats:p>","DOI":"10.1155\/2013\/352130","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T17:14:02Z","timestamp":1365527642000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["<i>Astragalus<\/i>\n                    in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome: Evidence-Based Clinical Practice"],"prefix":"10.1155","volume":"2013","author":[{"given":"Chuan","family":"Zou","sequence":"first","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Su","sequence":"additional","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchi","family":"Wu","sequence":"additional","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong Province 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1440-1754.1998.00232.x","volume":"34","year":"1998","journal-title":"Journal of Paediatrics and Child Health"},{"issue":"1","key":"2","first-page":"35","volume":"14","year":"1996","journal-title":"Chinese Journal of Clinical Pediatrics"},{"issue":"8","key":"3","first-page":"879","volume":"15","year":"2009","journal-title":"Journal of Hainan Medical College"},{"issue":"3","key":"4","first-page":"34","volume":"10","year":"2000","journal-title":"Chinese Journal of Nosocomiology"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0022-3476(86)80876-9","volume":"108","year":"1986","journal-title":"Journal of Pediatrics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.65297"},{"key":"7","first-page":"S142","volume":"88","year":"2005","journal-title":"Journal of the Medical Association of Thailand"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00285.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01850310"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.116079"},{"issue":"6","key":"11","first-page":"969","volume":"38","year":"2007","journal-title":"Journal of Sichuan University (Medical Science Edition)"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14184-0"},{"issue":"1","key":"13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/000992280204100110","volume":"41","year":"2002","journal-title":"Clinical Pediatrics"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003964.pub3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/1534735403256419"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006335.pub2"},{"issue":"12","key":"20","first-page":"718","volume":"6","year":"2005","journal-title":"Chinese Journal of Integrated Traditional and Western Nephrology"},{"issue":"5","key":"19","first-page":"467","volume":"28","year":"2008","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"05","key":"17","first-page":"9","volume":"32","year":"2010","journal-title":"Hubei Journal of Traditional Chinese Medicine"},{"issue":"09","key":"18","first-page":"846","volume":"23","year":"2008","journal-title":"Chinese Journal of Traditional Chinese Medicine"},{"issue":"7","key":"21","first-page":"413","volume":"5","year":"2004","journal-title":"Chinese Journal of Integrated Medicine"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1542\/peds.5.3.486","volume":"5","year":"1950","journal-title":"Pediatrics"},{"key":"25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/adc.35.180.115","volume":"35","year":"1960","journal-title":"Archives of disease in childhood"},{"issue":"7212","key":"26","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0140-6736(61)91026-1","volume":"278","year":"1961","journal-title":"The Lancet"},{"issue":"4","key":"27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1542\/peds.73.4.497","volume":"73","year":"1984","journal-title":"Pediatrics"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1056\/NEJM197507032930103","volume":"293","year":"1975","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1542\/peds.69.2.219","volume":"69","year":"1982","journal-title":"Pediatrics"},{"issue":"8","key":"30","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1203\/00006450-197708000-00012","volume":"11","year":"1977","journal-title":"Pediatric Research"},{"issue":"2","key":"31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0022-3476(82)80633-1","volume":"100","year":"1982","journal-title":"Journal of Pediatrics"},{"key":"32","first-page":"362","volume":"4","year":"2009","journal-title":"Journal of Cellular and Molecular Immunology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel030"},{"issue":"3","key":"34","first-page":"125","volume":"25","year":"1988","journal-title":"Journal of Clinical and Laboratory Immunology"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(90)90038-G"},{"issue":"3","key":"36","first-page":"146","volume":"10","year":"1995","journal-title":"Chinese Medical Sciences Journal"},{"issue":"6","key":"37","first-page":"422","volume":"3","year":"1998","journal-title":"Alternative Medicine Review"},{"issue":"7203","key":"38","first-page":"160","volume":"318","year":"1999","journal-title":"The British Medical Journal"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.12.007"},{"issue":"7652","key":"40","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/bmj.39493.646875.AE","volume":"336","year":"2008","journal-title":"The British Medical Journal"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.04.012"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/352130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/352130.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/352130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T06:48:00Z","timestamp":1644734880000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/352130\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":39,"alternative-id":["352130","352130"],"URL":"https:\/\/doi.org\/10.1155\/2013\/352130","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}