{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:19:15Z","timestamp":1791037155644,"version":"4.1.0"},"reference-count":160,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Direcci\u00f3n General de Apoyo al Personal Acad\u00e9mico (DGAPA)","award":["IN-211311"],"award-info":[{"award-number":["IN-211311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>T lymphocytes from the immune system are bone marrow-derived cells whose development and activities are carefully supervised by two sets of accessory cells. In the thymus, the immature young T lymphocytes are engulfed by epithelial \u201cnurse cells\u201d and retained in vacuoles, where most of them (95%) are negatively selected and removed when they have an incomplete development or express high affinity autoreactive receptors. The mature T lymphocytes that survive to this selection process leave the thymus and are controlled in the periphery by another subpopulation of accessory cells called \u201cregulatory cells,\u201d which reduce any excessive immune response and the risk of collateral injuries to healthy tissues. By different times and procedures, nurse cells and regulatory cells control both the development and the functions of T lymphocyte subpopulations. Disorders in the T lymphocytes development and migration have been observed in some parasitic diseases, which disrupt the thymic microenvironment of nurse cells. In other cases, parasites stimulate rather than depress the functions of regulatory T cells decreasing T-mediated host damages. This paper is a short review regarding some features of these accessory cells and their main interactions with T immature and mature lymphocytes. The modulatory role that neurotransmitters and hormones play in these interactions is also revised.<\/jats:p>","DOI":"10.1155\/2013\/352414","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T21:01:57Z","timestamp":1356555717000},"page":"1-15","source":"Crossref","is-referenced-by-count":9,"title":["The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses"],"prefix":"10.1155","volume":"2013","author":[{"given":"Mar\u00eda Guadalupe","family":"Reyes Garc\u00eda","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad Universitaria, 04510 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Garc\u00eda Tamayo","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunobiolog\u00eda, Departamento de 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