{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:01:36Z","timestamp":1740157296182,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Rheumatoid arthritis (RA) is a multisystem disease with a complex immunologic pathophysiology. Likewise, sleep disorders can involve a complicated interplay between the neurologic pathways, immune system, and respiratory system. Recent studies have shown an elevated prevalence of sleep abnormalities in connective tissue disorders compared to the general population. Restless legs syndrome (RLS) may be present in up to 30% of RA patients. These findings may be related to cytokine release and other immunomodulatory responses. TNF-<jats:italic>\u03b1<\/jats:italic>levels relate to sleep physiology and anti-TNF-<jats:italic>\u03b1<\/jats:italic>therapy may improve sleep patterns. Most of the patients with this disorder can distinguish their RLS sensations from their arthritic symptoms. RLS is a common comorbidity seen with RA, and prompt recognition and treatment can improve patient quality of life.<\/jats:p>","DOI":"10.1155\/2013\/352782","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T17:01:10Z","timestamp":1371056470000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Restless Legs Syndrome as a Comorbidity in Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-5520","authenticated-orcid":true,"given":"John A.","family":"Gjevre","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Saskatchewan, Saskatoon, SK, S7N0W8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-7607","authenticated-orcid":true,"given":"Regina M.","family":"Taylor Gjevre","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Saskatchewan, Saskatoon, SK, S7N0W8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00002826-198706000-00004","volume":"10","year":"1987","journal-title":"Clinical Neuropharmacology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100517"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00010-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120111"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.09.015"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.10.007"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.2.196"},{"issue":"14","key":"9","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1001\/archinte.160.14.2137","volume":"160","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.08.006"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168910.48309.4a"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.11.1286"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02067.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-007-0736-x"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/01.WNL.0000078887.16593.12","volume":"61","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/PL00007859","volume":"249","year":"2002","journal-title":"Journal of Neurology"},{"issue":"3","key":"17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/sleep\/34.3.341","volume":"34","year":"2011","journal-title":"Sleep"},{"issue":"7","key":"18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1056\/NEJMoa072743","volume":"357","year":"2007","journal-title":"The New England Journal of Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.09.001"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328333b9cc"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081335"},{"issue":"1","key":"22","first-page":"169","volume":"29","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318190f94c"},{"issue":"6521","key":"24","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/bmj.292.6521.659","volume":"292","year":"1986","journal-title":"British Medical Journal"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000184519.47689.c4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101039"},{"issue":"6","key":"27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/01.mcp.0000183062.98665.6b","volume":"11","year":"2005","journal-title":"Current Opinion in Pulmonary Medicine"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1159\/000104864"},{"key":"29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1749-6632.1998.tb08323.x","volume":"856","year":"1998","journal-title":"Annals of the New York Academy of Sciences"},{"key":"30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","volume":"7","year":"2007","journal-title":"Nature Reviews Immunology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007831"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X11416862"},{"issue":"11","key":"33","first-page":"2115","volume":"31","year":"2004","journal-title":"Journal of Rheumatology"},{"issue":"6","key":"34","first-page":"838","volume":"25","year":"2007","journal-title":"Clinical and Experimental Rheumatology"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.069690"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/art.30623"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.11.003"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007834"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.01.009"},{"issue":"3","key":"40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.phrs.2011.11.009","volume":"65","year":"2012","journal-title":"Pharmacological Research"}],"container-title":["Autoimmune Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2013\/352782.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2013\/352782.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2013\/352782.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T10:32:15Z","timestamp":1498041135000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ad\/2013\/352782\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":39,"alternative-id":["352782","352782"],"URL":"https:\/\/doi.org\/10.1155\/2013\/352782","relation":{},"ISSN":["2090-0422","2090-0430"],"issn-type":[{"type":"print","value":"2090-0422"},{"type":"electronic","value":"2090-0430"}],"subject":[],"published":{"date-parts":[[2013]]}}}