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This trial aims to look for the protein biomarker of \u201ctoxin syndrome\u201d of CHD patients.<jats:italic>Methods<\/jats:italic>. We have performed two trials in this paper. The first trial was a randomized controlled trial (RCT) of the plasma proteome in unstable angina (UA) patients by Maldi-Tof Mass. The second trial was a nested case-control study in 1503 stable CHD patients with one-year followup for acute cardiovascular events (ACEs).<jats:italic>Results<\/jats:italic>. In the RCT study, 12 protein spots were found to be the differential protein for the significant differences between the difference of before and after treatment in group A and group B; 2 of them (3207.37\u2009Da and 4279.95\u2009Da) was considered to be unique to \u201ctoxin syndrome\u201d for being differential proteins of group B but not group A. These 2 spots were identified as Isoform 1 of Fibrinogen alpha chain precursor (FGA, 3207.37\u2009Da) and Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4, 4279.95\u2009Da), respectively. In the nested case-control study, the result of Western blot demonstrated that protein expression of ITIH4 in the group with followup ACEs was significantly lower than the matched group without followup ACEs (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.027<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. ITIH4 might be a new potential biomarker of CHD \u201ctoxin syndrome\u201d in TCM, indicating the potential role in early identifying high-risk CHD patients in stable period.<\/jats:p>","DOI":"10.1155\/2013\/360149","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T21:01:04Z","timestamp":1376946064000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["ITIH4: A New Potential Biomarker of \u201cToxin Syndrome\u201d in Coronary Heart Disease Patient Identified with Proteomic Method"],"prefix":"10.1155","volume":"2013","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[{"name":"Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Shang","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China"},{"name":"Beijing University of 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