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Recently, we found that Th17 cells, a new helper T (Th) cell subset, were increased in patients with BD, and both Th type 1 (Th1) and Th17 cell differentiation signaling pathways were overactivated. Several researches revealed that genetic polymorphisms in Th1\/Th17 cell differentiation signaling pathways were associated with the onset of BD. Here, we summarize current findings on the Th cell subsets, their contribution to the pathogenesis of BD and the genetic backgrounds, especially in view of IL-12 family cytokine production and pattern recognition receptors of macrophages\/monocytes.<\/jats:p>","DOI":"10.1155\/2013\/363859","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T21:01:07Z","timestamp":1388437267000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet\u2019s Disease"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3270-4443","authenticated-orcid":true,"given":"Jun","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, 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