{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:16:23Z","timestamp":1765268183040},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian patient affected by anxiety disorder and treated with BZDs presented a severe case of dependence on BZDs. We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam), and looking at the methadone treatment model as paradigm. We decided to use clonazepam for its pharmacokinetic properties. The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level.<\/jats:p>","DOI":"10.1155\/2013\/367594","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T21:02:35Z","timestamp":1359579755000},"page":"1-4","source":"Crossref","is-referenced-by-count":13,"title":["Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report"],"prefix":"10.1155","volume":"2013","author":[{"given":"Angelo Giovanni Icro","family":"Maremmani","sequence":"first","affiliation":[{"name":"Vincent P. Dole Dual Diagnosis Unit, Department of Neurosciences, Santa Chiara University Hospital, University of Pisa, Via Roma, 67, 56100 Pisa, Italy"},{"name":"Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), Lucca, 55045 Pietrasanta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Rovai","sequence":"additional","affiliation":[{"name":"Vincent P. Dole Dual Diagnosis Unit, Department of Neurosciences, Santa Chiara University Hospital, University of Pisa, Via Roma, 67, 56100 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rugani","sequence":"additional","affiliation":[{"name":"Vincent P. 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