{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:28:49Z","timestamp":1740169729727,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Copenhagen HIV Programme","award":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"],"award-info":[{"award-number":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"],"award-info":[{"award-number":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"],"award-info":[{"award-number":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"],"award-info":[{"award-number":["CT94-1637","QLK2-2000-00773","LSHP-CT-2006-018632"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP).<jats:italic>Methods.<\/jats:italic>Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately.<jats:italic>Results.<\/jats:italic>A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4\u201361.6%), 12.3% for TBP (8.9\u201315.7%), and 19.4% for TBEP (16.1\u201322.6) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72\u20139.09), a prior AIDS diagnosis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>aIRR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>4.82<\/mml:mn><\/mml:math>(2.61\u20138.92)), and receiving care in Eastern Europe (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>aIRR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>5.41<\/mml:mn><\/mml:math>(2.58\u201311.34))).<jats:italic>Conclusions.<\/jats:italic>TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.<\/jats:p>","DOI":"10.1155\/2013\/373601","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T16:01:20Z","timestamp":1388505680000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["TB Meningitis in HIV-Positive Patients in Europe and Argentina: Clinical Outcome and Factors Associated with Mortality"],"prefix":"10.1155","volume":"2013","author":[{"given":"Anne Marie W.","family":"Efsen","sequence":"first","affiliation":[{"name":"Copenhagen HIV Programme, Rigshospitalet, Faculty of Health and Medical Sciences, Copenhagen University Hospital and University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Panteleev","sequence":"additional","affiliation":[{"name":"TB Hospital No. 2, Russian Federation, 195267 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grint","sequence":"additional","affiliation":[{"name":"University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria N.","family":"Podlekareva","sequence":"additional","affiliation":[{"name":"Copenhagen HIV Programme, Rigshospitalet, Faculty of Health and Medical Sciences, Copenhagen University Hospital and University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vassilenko","sequence":"additional","affiliation":[{"name":"Belorusian State Medical University, Minsk 220002, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aza","family":"Rakhmanova","sequence":"additional","affiliation":[{"name":"St. Petersburg AIDS Centre, 193167 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indra","family":"Zeltina","sequence":"additional","affiliation":[{"name":"Infectology Centre of Latvia, 1006 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo H.","family":"Losso","sequence":"additional","affiliation":[{"name":"Hospital JM Ramos Mejia, Servicio de Inmunocomprometidos, CP 1221 Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Miller","sequence":"additional","affiliation":[{"name":"Centre for Sexual Health & HIV Research, Mortimer Market Centre, University College London, London WC1E 6JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-5896","authenticated-orcid":true,"given":"Enrico","family":"Girardi","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Malattie Infettive L Spallanzani, 00149 Rome, 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