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In the control+DFX and contusion+DFX groups, 100\u2009mg\/kg DFX was given intraperitoneally once a day just after the contusion and the day after the contusion. Contusions led to a meaningful rise in the malondialdehyde (MDA) level in lung tissue. MDA levels in the contusion+DFX group experienced a significant decline. Glutathione levels were significantly lower in the contusion group than in the control group and significantly higher in the contusion+DFX group. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in the contusion group were significantly lower than those in the control group. In the contusion+DFX group, SOD and GPx levels were significantly higher than those in the contusion group. In light microscopic evaluation, the contusion and contusion+DFX groups showed edema, hemorrhage, alveolar destruction, and leukocyte infiltration. However, histological scoring of the contusion+DFX group was significantly more positive than that of the contusion group. The iNOS staining in the contusion group was significantly more intensive than that in all other groups. DFX reduced iNOS staining significantly in comparison to the contusion group. This study showed that DFX reduced oxidative stress in lung contusions in rats and histopathologically ensured the recovery of the lung tissue.<\/jats:p>","DOI":"10.1155\/2013\/376959","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T21:02:50Z","timestamp":1375390970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Desferrioxamine Reduces Oxidative Stress in the Lung Contusion"],"prefix":"10.1155","volume":"2013","author":[{"given":"Umit Nusret","family":"Basaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Ayvaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turan","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Cemek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan","family":"Karaboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Inan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Pul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2012.07.007"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04186.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241500750009654"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198912000-00013"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.3.240"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200108000-00003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000169725.80068.4a"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000224141.69216.aa"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.12.042"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1840469"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00682.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0432OC"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00123108"},{"key":"e_1_2_6_14_2","first-page":"S162","article-title":"Preventive therapy of experimental colitis with selected iron chelators and anti-oxidants","volume":"3","author":"Minaiyan M.","year":"2012","journal-title":"International Journal of Preventive Medicine"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.608228"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000180201.25746.1F"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.12.1539"},{"key":"e_1_2_6_18_2","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler E.","year":"1963","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05013-8"},{"key":"e_1_2_6_20_2","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia D. 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