{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:51:26Z","timestamp":1785876686824,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Total glucosides of paeony capsule (TGPC) and compound glycyrrhizin tablets (CGT) are plant extracts of glycosides. We conducted this study to examine the efficacy and safety of TGPC plus CGT for severe alopecia areata in children. 117 subjects were randomly allocated into TGPC plus CGT group or CGT group. For consecutive 12 months, subjects were given oral TGPC and CGT or oral CGT alone. The outcome measures included score of alopecia areata severity, effective rate, and adverse events observed in the 3rd, 6th, and 12th month. We found that the scores of alopecia areata severity of both groups were significantly reduced, and the scores of treatment group were lower than those of control group; for effective rate, there was no statistical difference between the two groups in the 3rd month, while in the 6th and 12th months the treatment group was superior compared with control group; the incidence rate of adverse events between the two groups was not statistically different, and no severe adverse events were observed. In conclusion, TGPC plus CGT appears effective and safe for severe alopecia areata in children.<\/jats:p>","DOI":"10.1155\/2013\/378219","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T21:28:47Z","timestamp":1380058127000},"page":"1-5","source":"Crossref","is-referenced-by-count":23,"title":["Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2013","author":[{"given":"Dingquan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-4296","authenticated-orcid":true,"given":"Jingwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueli","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China-Japan Friendship Hospital Affiliated to Ministry of Public Health, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"1","first-page":"318","volume":"35","year":"2009","journal-title":"International Journal of Dermatology and Venereology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.008"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11655-012-1173-0","volume":"18","year":"2012","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"4","year":"2010"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jaad.2003.09.032","volume":"51","year":"2004","journal-title":"Journal of the American Academy of Dermatology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.120.4.457"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.128.5.702"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01413.x"},{"issue":"23","key":"9","first-page":"13","year":"2006","journal-title":"Pediatric Dermatology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701183"},{"issue":"7","key":"11","first-page":"916","volume":"138","year":"2002","journal-title":"Archives of Dermatology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1159\/000131412"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.371"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"issue":"7","key":"15","first-page":"485","volume":"27","year":"2011","journal-title":"China Journal of Leprosy and Skin Diseases"},{"issue":"5","key":"16","first-page":"304","volume":"14","year":"2003","journal-title":"China Pharmacy"},{"issue":"4","key":"17","first-page":"349","volume":"23","year":"2007","journal-title":"China Journal of Leprosy and Skin Diseases"},{"issue":"1","key":"18","first-page":"48","volume":"12","year":"2008","journal-title":"Journal of Pediatric Pharmacy"},{"issue":"18","key":"19","first-page":"2011","volume":"18","year":"2009","journal-title":"Modern Journal of Integrated Chinese Traditional and Western Medicine"},{"issue":"5","key":"20","first-page":"455","volume":"30","year":"2010","journal-title":"Henan Traditional Chinese Medicine"},{"issue":"2","key":"21","first-page":"240","volume":"31","year":"2007","journal-title":"Journal of Zhejiang Traditional Chinese Medicine"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/378219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/378219.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/378219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T18:29:38Z","timestamp":1498069778000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/378219\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":21,"alternative-id":["378219","378219"],"URL":"https:\/\/doi.org\/10.1155\/2013\/378219","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}