{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:59:22Z","timestamp":1770991162099,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 84206"],"award-info":[{"award-number":["MOP 84206"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["NA 6747"],"award-info":[{"award-number":["NA 6747"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heart and Stroke Foundation of Ontario (HSFO)","award":["MOP 84206"],"award-info":[{"award-number":["MOP 84206"]}]},{"name":"Heart and Stroke Foundation of Ontario (HSFO)","award":["NA 6747"],"award-info":[{"award-number":["NA 6747"]}]},{"name":"Mount Sinai Hospital, Department of Medicine Postdoctoral","award":["MOP 84206"],"award-info":[{"award-number":["MOP 84206"]}]},{"name":"Mount Sinai Hospital, Department of Medicine Postdoctoral","award":["NA 6747"],"award-info":[{"award-number":["NA 6747"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p><jats:italic>Background\/Aims<\/jats:italic>. Gestational diabetes mellitus (GDM) and milder gestational impaired glucose tolerance (GIGT) identify women who are at risk of developing cardiovascular disease. Endothelial dysfunction, as indicated by impaired flow-mediated dilatation (FMD) on brachial artery ultrasound, is an early marker of vascular disease. Thus, we sought to evaluate endothelial function in women with and without recent glucose intolerance in pregnancy.<jats:italic>Methods<\/jats:italic>. One-hundred and seventeen women underwent oral glucose tolerance testing (OGTT) in pregnancy, enabling stratification into those with normal gestational glucose tolerance (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>59<\/mml:mn><\/mml:math>) and those with GDM or GIGT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>58<\/mml:mn><\/mml:math>). 6 years postpartum, they underwent a repeat of OGTT and brachial artery FMD studies, enabling assessment of FMD and 4 secondary vascular measures: FMD after 60 seconds (FMD<jats:sub>60<\/jats:sub>), baseline arterial diameter, peak shear rate, and reactive hyperemia.<jats:italic>Results<\/jats:italic>. There were no differences between the normal gestational glucose tolerance and GDM\/GIGT groups in FMD (mean 8.5 versus 9.3%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.61<\/mml:mn><\/mml:math>), FMD<jats:sub>60<\/jats:sub>(4.1 versus 5.1%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.33<\/mml:mn><\/mml:math>), baseline diameter (3.4 versus 3.4\u2009mm,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.66<\/mml:mn><\/mml:math>), peak shear rate (262.6 versus 274.8\u2009s<jats:sup>\u22121<\/jats:sup>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.32<\/mml:mn><\/mml:math>), and reactive hyperemia (576.6 versus 496.7%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.07<\/mml:mn><\/mml:math>). After covariate adjustment, there were still no differences between the groups.<jats:italic>Conclusion<\/jats:italic>. Despite their long-term cardiovascular risk, women with glucose intolerance in pregnancy do not display endothelial dysfunction 6 years postpartum.<\/jats:p>","DOI":"10.1155\/2013\/382670","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T17:01:12Z","timestamp":1369846872000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Endothelial Function in Women with and without a History of Glucose Intolerance in Pregnancy"],"prefix":"10.1155","volume":"2013","author":[{"given":"Shireen","family":"Brewster","sequence":"first","affiliation":[{"name":"Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada M5T 3L9"},{"name":"Division of Cardiology, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5"},{"name":"Division of Cardiology, University of Toronto, Toronto, ON, Canada M5S 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