{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:49:45Z","timestamp":1790758185266,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["FKZ01GI0924"],"award-info":[{"award-number":["FKZ01GI0924"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centre for Regenerative Therapy Dresden","award":["FKZ01GI0924"],"award-info":[{"award-number":["FKZ01GI0924"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care.<\/jats:p>","DOI":"10.1155\/2013\/385641","type":"journal-article","created":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T17:00:24Z","timestamp":1365354024000},"page":"1-6","source":"Crossref","is-referenced-by-count":183,"title":["Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus"],"prefix":"10.1155","volume":"2013","author":[{"given":"Elena","family":"Tsourdi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Barthel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany"},{"name":"Endokrinologikum Ruhr, 44866 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Rietzsch","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reichel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130303.x"},{"issue":"12, supplement 1","key":"3","first-page":"S122","volume":"30","year":"1990","journal-title":"Journal of Trauma"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","volume":"83","year":"2003","journal-title":"Physiological Reviews"},{"issue":"25","key":"5","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1056\/NEJM198412203112506","volume":"311","year":"1984","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1464-5491.1992.tb01790.x","volume":"9","year":"1992","journal-title":"Diabetic Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(05)80167-8"},{"issue":"7","key":"8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2337\/diabetes.50.7.1627","volume":"50","year":"2001","journal-title":"Diabetes"},{"issue":"8","key":"9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.ASW.0000358639.45784.cd","volume":"22","year":"2009","journal-title":"Advances in Skin & Wound Care"},{"issue":"2","key":"10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2337\/diacare.15.2.256","volume":"15","year":"1992","journal-title":"Diabetes Care"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5700"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0022-4804(91)90196-S","volume":"50","year":"1991","journal-title":"Journal of Surgical Research"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00692.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91085-Z"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031371"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90140-5"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-0625.1997.tb00164.x","volume":"6","year":"1997","journal-title":"Experimental Dermatology"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1523-1747.ep12359590","volume":"101","year":"1993","journal-title":"Journal of Investigative Dermatology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0868-8"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1067\/mva.2001.115379","volume":"33","year":"2001","journal-title":"Journal of Vascular Surgery"},{"key":"21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/dmrr.2246","volume":"28","year":"2012","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"1","key":"22","first-page":"24","volume":"10","year":"2012","journal-title":"Skinmed"},{"key":"23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/dmrr.2248","volume":"28","year":"2012","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"issue":"2","key":"24","volume":"15","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/dmrr.2240","volume":"28","year":"2012","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.07.024"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-8422(03)00072-7"},{"issue":"7","key":"28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.12968\/jowc.2008.17.7.30522","volume":"17","year":"2008","journal-title":"Journal of Wound Care"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2007.03.002"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.02.023"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1701"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2337\/diacare.24.2.290","volume":"24","year":"2001","journal-title":"Diabetes Care"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32169"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2121"},{"issue":"11","key":"35","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3727\/096368910X514288","volume":"19","year":"2010","journal-title":"Cell Transplantation"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.4.510"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29710"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00296-3"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0149"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1115203"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00134-X"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.822"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.2165\/11534570-000000000-00000"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-003-0065-3"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/dmrr.2242","volume":"28","year":"2012","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2007.01.0002"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2007.0240"},{"key":"49"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385641.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/385641.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T21:38:59Z","timestamp":1562881139000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2013\/385641\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":49,"alternative-id":["385641","385641"],"URL":"https:\/\/doi.org\/10.1155\/2013\/385641","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}