{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:39:34Z","timestamp":1775687974382,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30873285"],"award-info":[{"award-number":["30873285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Jian-Pi-Zhi-Dong Decoction (JPZDD) is dedicated to the treatment for Tourette syndrome (TS) with the guidance of the theories of Traditional Chinese Medicine (TCM). This study aims to investigate the expression of dopamine transporter (DAT) in the striatum and stereotyped behavior of TS mice model by intervention of JPZDD. Mice were induced by 3,3\u2032-iminodipropionitrile (IDPN, 350\u2009mg kg<jats:sup>\u22121<\/jats:sup>day<jats:sup>\u22121<\/jats:sup>, i.p.) for 7 days and divided into 4 groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:mrow><\/mml:math>, each): control and IDPN groups were gavaged with saline and the remaining 2 groups with Tiapride (Tia, 50\u2009mg kg<jats:sup>\u22121<\/jats:sup>day<jats:sup>\u22121<\/jats:sup>) and JPZDD (20\u2009g kg<jats:sup>\u22121<\/jats:sup>day<jats:sup>\u22121<\/jats:sup>), respectively. The results showed that the scores of stereotyped behavior in IDPN+JPZDD group were significantly reduced. A noticeably increased<jats:sup>11<\/jats:sup>C-<jats:italic>\u03b2<\/jats:italic>-CFT binding at bilateral striatum was observed after administration of JPZDD versus that of IDPN or Tia. Immunohistochemistry and in situ hybridization studies manifested higher levels of DAT protein and mRNA in IDPN+JPZDD group. These findings not only demonstrated that JPZDD could effectively inhibit the abnormal behaviors of TS mice model, but also increase the level of DAT in striatum. Therefore, JPZDD could be one of potential treatments of patients with TS.<\/jats:p>","DOI":"10.1155\/2013\/385685","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T16:03:18Z","timestamp":1359993798000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Chinese Medicine Formula \u201cJian-Pi-Zhi-Dong Decoction\u201d Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice"],"prefix":"10.1155","volume":"2013","author":[{"given":"Dao-han","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.09.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.03.006"},{"issue":"95","key":"3","first-page":"112","volume":"81","year":"2005","journal-title":"Postgraduate Medical Journal"},{"key":"4","first-page":"1035","volume-title":"Tourette syndrome as a neurotransmitter disorder","year":"2009"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301528"},{"issue":"20","key":"6","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1523\/JNEUROSCI.19-20-09141.1999","volume":"19","year":"1999","journal-title":"The Journal of Neuroscience"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.01.004"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1523\/JNEUROSCI.18-06-01979.1998","volume":"18","year":"1998","journal-title":"The Journal of Neuroscience"},{"issue":"10","key":"9","first-page":"81","volume":"24","year":"2006","journal-title":"Journal of Sichuan of Traditional Chinese Medicine"},{"key":"10","first-page":"221","volume":"35","year":"1982","journal-title":"Advances in Neurology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp043"},{"issue":"3","key":"12","first-page":"142","volume":"25","year":"2005","journal-title":"Chinese Journal of Nuclear Medicine"},{"issue":"3-4","key":"13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s004269900007","volume":"63","year":"2000","journal-title":"Psychological Research"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(02)00066-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.06.002"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1212\/WNL.46.4.965","volume":"46","year":"1996","journal-title":"Neurology"},{"issue":"2","key":"17","first-page":"49","volume":"20","year":"2012","journal-title":"Acta Laboratorium Animalis Scientia Sinica"},{"issue":"8","key":"18","first-page":"1087","volume":"27","year":"2007","journal-title":"Chinese Journal of Hospital Pharmacy"},{"issue":"2","key":"19","first-page":"268","volume":"31","year":"2008","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.08.006"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/636091"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.10.010"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01191.x"},{"issue":"1","key":"24","first-page":"1","volume":"18","year":"2011","journal-title":"Journal of Beijing University of Traditional Chinese Medicine (Clinical Medicine)"},{"issue":"12","key":"25","first-page":"38","volume":"16","year":"2009","journal-title":"Chinese Journal of Information on Traditional Chinese Medicine"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-3-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00611-S"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000117171","volume":"30","year":"1990","journal-title":"European Neurology"},{"issue":"4","key":"29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00449911","volume":"237","year":"1988","journal-title":"European Archives of Psychiatry and Neurological Sciences"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827171"},{"key":"31","doi-asserted-by":"crossref","first-page":"29s","DOI":"10.1016\/S0924-9338(00)00526-5","volume":"16","year":"2001","journal-title":"European Psychiatry"},{"issue":"4","key":"32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00787-011-0163-7","volume":"20","year":"2011","journal-title":"European Child and Adolescent Psychiatry"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104040251"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/385685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/385685.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/385685.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T02:55:45Z","timestamp":1562640945000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2013\/385685\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":33,"alternative-id":["385685","385685"],"URL":"https:\/\/doi.org\/10.1155\/2013\/385685","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}