{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:27:33Z","timestamp":1740166053058,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutics"],"published-print":{"date-parts":[[2013,1,20]]},"abstract":"<jats:p>Bladder pain is a characteristic disorder of interstitial cystitis. Diazepam is well known for its antispasmodic activity in the treatment of muscular hypertonus. The aim of this work was to develop and characterize vaginal pessaries as an intravaginal delivery system of diazepam for the treatment of interstitial cystitis. In particular, the performance of two types of formulations, with and without beta-glucan, was compared. In particular, the preparation of pessaries, according to the modified Pharmacopeia protocol, the setup of the analytical method to determine diazepam, pH evaluation, dissolution profile, and photostability assay were reported. Results showed that the modified protocol permitted obtaining optimal vaginal pessaries, without air bubbles, with good consistency and handling and with good pH profiles. In order to determine the diazepam amount, calibration curves with good correlation coefficients were obtained, by the spectrophotometric method, using placebo pessaries as matrix with the addition of diazepam standard solution. This method was demonstrated sensible and accurate to determine the amount of drug in batches. Dissolution profiles showed a complete diazepam release just after 15 minutes, even if beta-glucan pessaries released drug more gradually. Finally, a possible drug photodegradation after exacerbated UV-visible exposition was evaluated.<\/jats:p>","DOI":"10.1155\/2013\/386546","type":"journal-article","created":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T21:00:31Z","timestamp":1358715631000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Innovative Approach for Interstitial Cystitis: Vaginal Pessaries Loaded Diazepam\u2014A Preliminary Study"],"prefix":"10.1155","volume":"2013","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-8532","authenticated-orcid":true,"given":"P.","family":"Capra","sequence":"first","affiliation":[{"name":"Department of Urology, San Matteo Hospital of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Perugini","sequence":"additional","affiliation":[{"name":"Department of Drug Science, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bleve","sequence":"additional","affiliation":[{"name":"Department of Drug Science, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pavanetto","sequence":"additional","affiliation":[{"name":"Department of Drug Science, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Musitelli","sequence":"additional","affiliation":[{"name":"Department of Drug Science, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rovereto","sequence":"additional","affiliation":[{"name":"Department of Urology, San Matteo Hospital of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Porru","sequence":"additional","affiliation":[{"name":"Department of Urology, San Matteo Hospital of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1252-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.2001.00235.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.18.1922"},{"issue":"3","key":"4","first-page":"251","volume":"55","year":"2005","journal-title":"Acta Pharmaceutica"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00156-8"},{"year":"1996","key":"6"},{"issue":"2","key":"7","first-page":"21","volume":"16","year":"2007","journal-title":"Iraqi Journal of Pharmaceutical Sience"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-1075-7"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.59566\/IJBS.2007.3050","volume":"3","year":"2007","journal-title":"International Journal of Biomedical Sciences"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05257.x"},{"issue":"779","key":"14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/pgmj.66.779.727","volume":"66","year":"1990","journal-title":"Postgraduate Medical Journal"},{"key":"15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2165\/00002018-199614040-00005","volume":"14","year":"1996","journal-title":"Drug Safety"},{"key":"16","first-page":"31","volume":"128","year":"1995","journal-title":"Canadian Pharmaceutical Journal"},{"key":"17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/poc.861","volume":"18","year":"2005","journal-title":"Journal of Physical Organic Chemistry"}],"container-title":["Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/386546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/386546.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2013\/386546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T22:21:13Z","timestamp":1714861273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jphar\/2013\/386546\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,20]]},"references-count":14,"alternative-id":["386546","386546"],"URL":"https:\/\/doi.org\/10.1155\/2013\/386546","relation":{},"ISSN":["2090-9918","2090-7818"],"issn-type":[{"type":"print","value":"2090-9918"},{"type":"electronic","value":"2090-7818"}],"subject":[],"published":{"date-parts":[[2013,1,20]]}}}