{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:30:53Z","timestamp":1791307853759,"version":"4.3.1"},"reference-count":83,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Phospholipases type A<jats:sub>2<\/jats:sub>(PLA<jats:sub>2<\/jats:sub>s) are the most abundant proteins found in Viperidae snake venom. They are quite fascinating from both a biological and structural point of view. Despite similarity in their structures and common catalytic properties, they exhibit a wide spectrum of pharmacological activities. Besides being hydrolases, secreted phospholipases A<jats:sub>2<\/jats:sub>(sPLA<jats:sub>2<\/jats:sub>) are an important group of toxins, whose action at the molecular level is still a matter of debate. These proteins can display toxic effects by different mechanisms. In addition to neurotoxicity, myotoxicity, hemolytic activity, antibacterial, anticoagulant, and antiplatelet effects, some venom PLA<jats:sub>2<\/jats:sub>s show antitumor and antiangiogenic activities by mechanisms independent of their enzymatic activity. This paper aims to discuss original finding against anti-tumor and anti-angiogenic activities of sPLA<jats:sub>2<\/jats:sub>isolated from Tunisian vipers:<jats:italic>Cerastes cerastes<\/jats:italic>and<jats:italic>Macrovipera lebetina<\/jats:italic>, representing new tools to target specific integrins, mainly, and integrins.<\/jats:p>","DOI":"10.1155\/2013\/391389","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T21:01:16Z","timestamp":1359666076000},"page":"1-9","source":"Crossref","is-referenced-by-count":26,"title":["Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A<sub>2<\/sub>"],"prefix":"10.1155","volume":"2013","author":[{"given":"Raoudha","family":"Zouari-Kessentini","sequence":"first","affiliation":[{"name":"Laboratoire des Venins et Biomolecules Therapeutiques, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia"},{"name":"Universit\u00e9 de Tunis el Manar, 1068 Tunis, 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